ArticleThe Journal of comparative neurology2015
Convergence of Lemniscal and Local Excitatory Inputs on Large GABAergic Tectothalamic Neurons.
Article in The Journal of comparative neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Age-related differences in asymmetric synapses across the central inferior colliculus in the Fischer Brown Norway rat.Aging brain · 2026Article
- Segregated input to thalamic areas that project differently to core and shell auditory cortical fields.iScience · 2025Article
- Listening to your partner: serotonin increases male responsiveness to female vocal signals in mice.Frontiers in human neuroscience · 2023Article
- The role of GABAFrontiers in endocrinology · 2023Review
- Exclusive labeling of direct and indirect pathway neurons in the mouse neostriatum by an adeno-associated virus vector with Cre/lox system.STAR protocols · 2021Article
- Juxtacellular Labeling of Stellate, Disk and Basket Neurons in the Central Nucleus of the Guinea Pig Inferior Colliculus.Frontiers in neural circuits · 2021Article
- A novel class of inferior colliculus principal neurons labeled in vasoactive intestinal peptide-Cre mice.eLife · 2019Article
- Organization of projection from brainstem auditory nuclei to the inferior colliculus of Japanese house bat (Pipistrellus abramus).Brain and behavior · 2018Article
- Neuronal Organization in the Inferior Colliculus Revisited with Cell-Type-Dependent Monosynaptic Tracing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Inhibitory Neural Circuits in the Mammalian Auditory Midbrain.Journal of experimental neuroscience · 2018Review
- Neurochemical differences between target-specific populations of rat dorsal raphe projection neurons.Brain research · 2017Article
- Extracellular Molecular Markers and Soma Size of Inhibitory Neurons: Evidence for Four Subtypes of GABAergic Cells in the Inferior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Functional organization of the local circuit in the inferior colliculus.Anatomical science international · 2016Article
- Functional organization of the mammalian auditory midbrain.The journal of physiological sciences : JPS · 2015Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Large GABAergic (LG) neurons form a distinct cell type in the inferior colliculus (IC), identified by the presence of dense VGLUT2-containing axosomatic terminals. Although some of the axosomatic terminals originate from local and commissural IC neurons, it has been unclear whether LG neurons also receive axosomatic inputs from the lower auditory brainstem nuclei, i.e., cochlear nuclei (CN), superior olivary complex (SOC), and nuclei of the lateral lemniscus (NLL). In this study we injected recombinant viral tracers that force infected cells to express GFP in a Golgi-like manner into the lower auditory brainstem nuclei to determine whether these nuclei directly innervate LG cell somata. Labeled axons from CN, SOC, and NLL terminated as excitatory axosomatic endings, identified by colabeling of GFP and VGLUT2, on single LG neurons in the IC. Each excitatory axon made only a few axosomatic contacts on each LG neuron. Inputs to a single LG cell are unlikely to be from a single brainstem nucleus, since lesions of individual nuclei failed to eliminate most VGLUT2-positive terminals on the LG neurons. The estimated number of inputs on a single LG cell body was almost proportional to the surface area of the cell body. Double injections of different viruses into IC and a brainstem nucleus showed that LG neurons received inputs from both. These results demonstrated that both ascending and intrinsic sources converge on the LG somata to control inhibitory tectothalamic projections.
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