ArticlePLoS computational biology2015
The role of inhibition in a computational model of an auditory cortical neuron during the encoding of temporal information.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- A spatial code for temporal information is necessary for efficient sensory learning.Science advances · 2025Article
- Quantitative models of auditory cortical processing.Hearing research · 2023Review
- Article
- Distinct neuronal types contribute to hybrid temporal encoding strategies in primate auditory cortex.PLoS biology · 2022Article
- The role of adaptation in generating monotonic rate codes in auditory cortex.PLoS computational biology · 2020Article
- Inferring and validating mechanistic models of neural microcircuits based on spike-train data.Nature communications · 2019Article
- Spectral tuning of adaptation supports coding of sensory context in auditory cortex.PLoS computational biology · 2019Article
- The rough sound of salience enhances aversion through neural synchronisation.Nature communications · 2019Article
- Computational Neural Modeling of Auditory Cortical Receptive Fields.Frontiers in computational neuroscience · 2019Article
- Does Auditory Cortex Code Temporal Information from Acoustic and Cochlear Implant Stimulation in a Similar Way?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Distinct Subthreshold Mechanisms Underlying Rate-Coding Principles in Primate Auditory Cortex.Neuron · 2016Article
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Abstract
In auditory cortex, temporal information within a sound is represented by two complementary neural codes: a temporal representation based on stimulus-locked firing and a rate representation, where discharge rate co-varies with the timing between acoustic events but lacks a stimulus-synchronized response. Using a computational neuronal model, we find that stimulus-locked responses are generated when sound-evoked excitation is combined with strong, delayed inhibition. In contrast to this, a non-synchronized rate representation is generated when the net excitation evoked by the sound is weak, which occurs when excitation is coincident and balanced with inhibition. Using single-unit recordings from awake marmosets (Callithrix jacchus), we validate several model predictions, including differences in the temporal fidelity, discharge rates and temporal dynamics of stimulus-evoked responses between neurons with rate and temporal representations. Together these data suggest that feedforward inhibition provides a parsimonious explanation of the neural coding dichotomy observed in auditory cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.