ArticleHuman brain mapping2015
Pathological uncoupling between amplitude and connectivity of brain fluctuations in epilepsy.
Article in Human brain mapping, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Abnormalities of regional brain function in Parkinson's disease: a meta-analysis of resting state functional magnetic resonance imaging studies.Scientific reports · 2017Pooled it
- Integrating multivariate resting-state fMRI features to localize epileptic networks in common childhood epilepsy.Epilepsia · 2026Article
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- Recruitment patterns of hothubs and dark functional networks correlating activity and connectivity with magnetoencephalography.Scientific reports · 2026Article
- Convergent functional networks of intrinsic activity alterations in temporal lobe epilepsy and their molecular correlates.Frontiers in molecular neuroscience · 2026Article
- Obesity-related alterations of intrinsic functional architecture: a resting-state fMRI study based on the human connectome project.Frontiers in nutrition · 2025Article
- Alterations in spatiotemporal characteristics of dynamic networks in juvenile myoclonic epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Mapping Functional Connectivity Signatures of Pharmacoresistant Focal Cortical Dysplasia-Related Epilepsy.Annals of neurology · 2024Article
- Altered static and dynamic indices of intrinsic brain activity in patients with subcortical ischemic vascular disease: a resting-state functional magnetic resonance imaging analysis.Neuroradiology · 2023Article
- Multilayer brain network modeling and dynamic analysis of juvenile myoclonic epilepsy.Frontiers in behavioral neuroscience · 2023Article
- Characterization of resting functional MRI activity alterations across epileptic foci and networks.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Reliability and availability of granger causality density in localization of Rolandic focus in BECTS.Brain imaging and behavior · 2021Article
- Decreased modulation of segregated SEEKING and selective attention systems in chronic insomnia.Brain imaging and behavior · 2021Article
- Recurrent and concurrent patterns of regional BOLD dynamics and functional connectivity dynamics in cognitive decline.Alzheimer's research & therapy · 2021Article
- Reducing Inter-Site Variability for Fluctuation Amplitude Metrics in Multisite Resting State BOLD-fMRI Data.Neuroinformatics · 2021Article
- Dynamic state with covarying brain activity-connectivity: On the pathophysiology of schizophrenia.NeuroImage · 2021Article
- Disrupted topological properties of functional networks in epileptic children with generalized tonic-clonic seizures.Brain and behavior · 2020Article
- Article
- Impaired Topological Properties of Gray Matter Structural Covariance Network in Epilepsy Children With Generalized Tonic-Clonic Seizures: A Graph Theoretical Analysis.Frontiers in neurology · 2020Article
- The Role of EEG-fMRI in Studying Cognitive Network Alterations in Epilepsy.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amplitude and functional connectivity are two fundamental parameters for describing the spontaneous brain fluctuations. These two parameters present close coupling in physiological state, and present different alteration patterns in epilepsy revealed by functional MRI (fMRI). We hypothesized that the alteration of coupling between these two imaging parameters may be underpinned by specific pathological factors of epilepsy, and can be employed to improve the capability for epileptic focus detection. Forty-seven patients (26 left- and 21 right-sided) with mesial temporal lobe epilepsy (mTLE) and 32 healthy controls underwent resting-state fMRI scans. All patients were detected to have interictal epileptic discharges on simultaneous electroencephalograph (EEG) recordings. Amplitude-connectivity coupling was calculated by correlating amplitude and functional connectivity density of low-frequency brain fluctuations. We observed reduced amplitude-connectivity coupling associated with epileptic discharges in the mesial temporal regions in both groups of patients, and increased coupling associated with epilepsy durations in the posterior regions of the default-mode network in the right-sided patients. Moreover, we proposed a new index of amplitude subtracting connectivity, which elevated imaging contrast for differentiating the patients from the controls. The findings indicated that epileptic discharges and chronic damaging effect of epilepsy might both contribute to alterations of amplitude-connectivity coupling in different pivotal regions in mTLE. Investigation on imaging coupling provides synergistic approach for describing brain functional changing features in epilepsy.
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