ArticleBMC evolutionary biology2015
The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Transcriptomic Analysis of the Rainbow Trout Response to Single and Co-Infections withInternational journal of molecular sciences · 2025Article
- Adamts9 is required for the development of primary ovarian follicles and maintenance of female sex in zebrafish†.Biology of reproduction · 2024Article
- Dynamic and broad expression of adamts9 in developing and adult zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Phylogenetic inference of the emergence of sequence modules and protein-protein interactions in the ADAMTS-TSL family.PLoS computational biology · 2023Article
- Zebrafish as a Model to Study Vascular Elastic Fibers and Associated Pathologies.International journal of molecular sciences · 2022Review
- ADAMTS6: Emerging roles in cardiovascular, musculoskeletal and cancer biology.Frontiers in molecular biosciences · 2022Review
- Adamts10 controls transforming growth factorFrontiers in molecular biosciences · 2022Article
- Metalloproteases in gonad formation and ovulation.General and comparative endocrinology · 2021Review
- Delay in primordial germ cell migration in adamts9 knockout zebrafish.Scientific reports · 2021Article
- Regulation of ADAMTS Proteases.Frontiers in molecular biosciences · 2021Review
- The ADAMTS/Fibrillin Connection: Insights into the Biological Functions of ADAMTS10 and ADAMTS17 and Their Respective Sister Proteases.Biomolecules · 2020Review
- Review
- Genomic signatures and correlates of widespread population declines in salmon.Nature communications · 2019Article
- The ADAMTS5 Metzincin Regulates Zebrafish Somite Differentiation.International journal of molecular sciences · 2018Article
- Candidate gene identification of ovulation-inducing genes by RNA sequencing with an in vivo assay in zebrafish.PloS one · 2018Article
- Transcriptomic signatures for ovulation in vertebrates.General and comparative endocrinology · 2017Article
- Whole Genome Duplications Shaped the Receptor Tyrosine Kinase Repertoire of Jawed Vertebrates.Genome biology and evolution · 2016Article
- The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family.Genome biology · 2015Review
- The evolutionary conservation of the A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motif metzincins across vertebrate species and their expression in teleost zebrafish.BMC evolutionary biology · 2015Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe A Disintegrin-like and Metalloproteinase domain with Thrombospondin-1 motifs (ADAMTS) enzymes comprise 19 mammalian zinc-dependent metalloproteinases (metzincins) with homologues in a wide range of invertebrates. ADAMTS enzymes have a broad range of functions in development and diseases due to their extracellular matrix remodelling activity. Here, we report a detailed characterisation of their evolutionary conservation across vertebrates.
resultsUsing bioinformatics complemented with de novo sequencing, gene sequences for ADAMTS enzymes were obtained from a variety of organisms. Detailed evolutionary analyses revealed a high level of conservation across vertebrates with evidence of ADAMTS gene expansion during two rounds of whole genome duplication (WGD) in vertebrates, while tandem duplication events and gene loss were also apparent. However, the additional round of teleost-specific WGD did not have a significant effect on ADAMTS gene family members suggesting their conserved roles have remained constant in teleost fish. Quantitative reverse-transcriptase polymerase chain reaction analysis revealed dynamic expression of adamts genes throughout zebrafish embryonic development reflecting the key conserved roles they play in vertebrate embryogenesis. Notably, several adamts mRNAs were maternally expressed with a dramatic increase in mRNA levels coinciding with zygotic expression and organogenesis. Broad adamts mRNA expression was also demonstrated in several adult organs indicating potential roles in adult homeostasis.
conclusionsOur data highlight the evolution of the ADAMTS gene family through duplication processes across metazoans supplemented by a burst of amplification through vertebrate WGD events. It also strongly posits the zebrafish as a potential model species to further elucidate the function of ADAMTS enzymes during vertebrate development.
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