ArticleMolecular medicine (Cambridge, Mass.)2015
Interleukin-37 Expression Is Increased in Chronic HIV-1-Infected Individuals and Is Associated with Inflammation and the Size of the Total Viral Reservoir.
Article in Molecular medicine (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review).International journal of molecular medicine · 2026Review
- Interleukin-37 suppresses the cytotoxicity of hepatitis B virus peptides-induced CD8+ T cells in patients with acute hepatitis B.Biomolecules & biomedicine · 2023Article
- SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity.EBioMedicine · 2021Article
- Current Understanding of IL-37 in Human Health and Disease.Frontiers in immunology · 2021Review
- Potential role of IL-37 in atherosclerosis.Cytokine · 2019Review
- Cynomolgus macaque IL37 polymorphism and control of SIV infection.Scientific reports · 2019Article
- Interleukin 30 to Interleukin 40.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2018Review
- Soluble CD163 and soluble CD14 plasma levels but not cellular HIV-DNA decrease during successful interferon-free anti-HCV therapy in HIV-1-HCV co-infected patients on effective combined anti-HIV treatment.Medical microbiology and immunology · 2018Article
- Interleukin-37: A crucial cytokine with multiple roles in disease and potentially clinical therapy.Oncology letters · 2018Article
- Overview of the IL-1 family in innate inflammation and acquired immunity.Immunological reviews · 2018Review
- Reviews of Interleukin-37: Functions, Receptors, and Roles in Diseases.BioMed research international · 2018Review
- The potential of interleukin-37 as an effective therapeutic agent in asthma.Respiratory research · 2017Review
- The Role of IL-37 in Non-Cancerous Diseases.Pathology oncology research : POR · 2017Review
- Development and characterization of monoclonal antibody against human IL-37b.Cytotechnology · 2017Article
- Tuberculosis-sensitized monocytes sustain immune response of interleukin-37.Molecular immunology · 2016Article
- Suppression of innate inflammation and immunity by interleukin-37.European journal of immunology · 2016Review
- Residual inflammation and viral reservoirs: alliance against an HIV cure.Current opinion in HIV and AIDS · 2016Review
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Authors and funding
12 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interleukin-37 (IL-37) is a recently identified cytokine with potent antiinflammatory and immunosuppressive functions. The objective of this study was to compare levels of IL-37 mRNA in immunological subgroups of chronic human immunodeficiency virus-1 (HIV-1)-infected individuals and noninfected controls, to determine IL-37's association with biomarkers of inflammation and reservoir size. This was a cross-sectional study. The HIV-1-infected patients were categorized in three subgroups depending on their combination antiretroviral therapy (cART) treatment status and CD4(+) T-cell count. Quantitative RT-PCR was used for the detection of IL-37 mRNA and HIV-1 DNA in peripheral blood mononuclear cells (PBMCs). Biomarkers in plasma were quantified by enzyme-linked immunosorbent assay (ELISA), whereas T-cell activation was determined by flow cytometry. Lastly, lipopolysaccharide (LPS) stimulations of patients PBMCs were carried out to determine differences in IL-37 mRNA response between the subgroups. Sixty HIV-1-infected patients and 20 noninfected controls were included in the study. Steady-state IL-37 mRNA levels in PBMCs were significantly higher in HIV-1-infected individuals compared with noninfected controls: 2.4-fold (p ≤ 0.01) cART-naïve subjects; 3.9-fold (p ≤ 0.0001) inadequate immunological responders; and 4.0-fold (p ≤ 0.0001) in immunological responders compared with non-infected controls. Additionally, levels of the monocyte inflammatory marker sCD14 correlated with IL-37 mRNA (p = 0.03), whereas there was no association with T-cell activation. Finally, we observed a significant correlation between total viral HIV-1 DNA and IL-37 mRNA in PBMCs (p < 0.0001). Collectively, our data shows that the level of IL-37 mRNA is affected by chronic HIV-1-infection. A relationship with the activation of the monocyte compartment is suggested by the correlation with sCD14 and, interestingly, IL-37 could be related to the size of the total viral HIV-1 reservoir.
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