ArticleMolecular medicine (Cambridge, Mass.)2015
Resveratrol Improves Survival and Prolongs Life Following Hemorrhagic Shock.
Article in Molecular medicine (Cambridge, Mass.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Regulating mitochondrial metabolism by targeting pyruvate dehydrogenase with dichloroacetate, a metabolic messenger.Biochimica et biophysica acta. Molecular basis of disease · 2023Review
- Innate immunity and immunotherapy for hemorrhagic shock.Frontiers in immunology · 2022Review
- Regulation of NADMetabolism: clinical and experimental · 2022Review
- Improved Cardiovascular Tolerance to Hemorrhage after Oral Resveratrol Pretreatment in Dogs.Veterinary sciences · 2021Article
- Longevity pathways in stress resistance: targeting NAD and sirtuins to treat the pathophysiology of hemorrhagic shock.GeroScience · 2021Article
- Sirtuin 1: A Dilemma in Transplantation.Journal of transplantation · 2020Review
- Resveratrol pretreatment alleviates myocardial ischemia/reperfusion injury by inhibiting STIM1-mediated intracellular calcium accumulation.Journal of physiology and biochemistry · 2019Article
- A Combination Treatment Strategy for Hemorrhagic Shock in a Rat Model Modulates Autophagy.Frontiers in medicine · 2019Article
- Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock.JCI insight · 2018Article
- Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage.Experimental and therapeutic medicine · 2018Article
- Mitochondrial function in hypoxic ischemic injury and influence of aging.Progress in neurobiology · 2017Review
- Mitochondrial dysfunction in rat splenocytes following hemorrhagic shock.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Attenuation of Multiple Organ Damage by Continuous Low-Dose Solvent-Free Infusions of Resveratrol after Severe Hemorrhagic Shock in Rats.Nutrients · 2017Article
- Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock.Scientific reports · 2017Article
- Sirt1: Role Under the Condition of Ischemia/Hypoxia.Cellular and molecular neurobiology · 2017Review
- Alteration of cytokine profile following hemorrhagic shock.Cytokine · 2016Article
- Sirtuin regulation in aging and injury.Biochimica et biophysica acta · 2015Review
- Polydatin Alleviates Small Intestine Injury during Hemorrhagic Shock as a SIRT1 Activator.Oxidative medicine and cellular longevity · 2015Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Resveratrol has been shown to potentiate mitochondrial function and extend longevity; however, there is no evidence to support whether resveratrol can improve survival or prolong life following hemorrhagic shock. We sought to determine whether (a) resveratrol can improve survival following hemorrhage and resuscitation and (b) prolong life in the absence of resuscitation. Using a hemorrhagic injury (HI) model in the rat, we describe for the first time that the naturally occurring small molecule, resveratrol, may be an effective adjunct to resuscitation fluid. In a series of three sets of experiments we show that resveratrol administration during resuscitation improves survival following HI (p < 0.05), resveratrol and its synthetic mimic SRT1720 can significantly prolong life in the absence of resuscitation fluid (<30 min versus up to 4 h; p < 0.05), and resveratrol as well as SRT1720 restores left ventricular function following HI. We also found significant changes in the expression level of mitochondria-related transcription factors Ppar-α and Tfam, as well as Pgc-1α in the left ventricular tissues of rats subjected to HI and treated with resveratrol. The results indicate that resveratrol is a strong candidate adjunct to resuscitation following severe hemorrhage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.