Evidence map›Paper›PMID 25879513›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

Excessive Sugar Consumption May Be a Difficult Habit to Break: A View From the Brain and Body.

Matthew S Tryon, Kimber L Stanhope, Elissa S Epel, Ashley E Mason, Rashida Brown, Valentina Medici, Peter J Havel, Kevin D Laugero

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06107231 (WHNRC), which is not on this map. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06107231 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

WHNRC (Western Human Nutrition Research Center) Honey Study

TypeinterventionalSponsorUSDA, Western Human Nutrition Research CenterRan2024 to 2026Enrolled58ConditionsPostprandial Glycemia, Metabolic Stress, Cognitive Change, Satisfaction, PersonalArmsHoney, Sucrose, Honey plus almonds, Sucrose plus almonds
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 126 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A Brief Motivational Intervention Differentially Reduces Sugar-sweetened Beverage (SSB) Consumption.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2021
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  15. Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Matthew S TryonDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Kimber L StanhopeDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Elissa S EpelDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Ashley E MasonDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Rashida BrownDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Valentina MediciDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Peter J HavelDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
Kevin D LaugeroDepartments of Nutrition (M.S.T., K.L.S., K.D.L., P.J.H.) and Molecular Biosciences (P.J.H.), School of Veterinary Medicine, and Division of Gastroenterology and Hepatology (V.M.), School of Medicine, University of California, Davis, and Stress Biology and Nutrition Research Laboratory (K.D.L.), Obesity and Metabolism Research Unit, Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Davis, California 95616; and Department of Psychiatry (E.S.E., A.E.M., R.B.), University of California, San Francisco, San Francisco, California 94143.
University of California, San Francisco · USUniversity of California, Davis · USWestern Human Nutrition Research Center · US

Funding

UC DAVIS CLINICAL AND TRANSLATIONAL SCIENCE CENTER: BPCAUL1RR024146 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BERGLUND, LARS F · 2006 to 2011
$27.0M
Building Interdisciplinary Research Careers in Womens Health at UC Davis - Administrative SupplementK12HD051958 · NICHD · UNIVERSITY OF CALIFORNIA DAVIS · PI LANE, NANCY E · 2005 to 2023
$9.6M
Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
Adverse Metabolic Effects of Dietary Sugar _ Ad Libitum vs Energy-Balanced DietsR01HL121324 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2014 to 2019
$4.2M
Effects of 2wk fructose & HFCS consumption on lipid dysregulation & insulin resisR01HL091333 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J · 2008 to 2012
$2.0M
Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemiaR01HL107256 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HAVEL, PETER J, SCHWARZ, JEAN-MARC · 2011 to 2014
$1.5M
MAST CELL MATRIX METALLOPROTEINASES IN LUNG REMODELINGF32HL009133 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI FANG, KENNETH C · 1994 to 1995
–
NCCIH NIH HHS T32 AT003997NCRR NIH HHS UL1 RR024146NHLBI NIH HHS 1R01HL09133NHLBI NIH HHS 1R01HL107256NHLBI NIH HHS F32 HL009133NHLBI NIH HHS R01 HL091333NHLBI NIH HHS R01 HL107256NHLBI NIH HHS R01 HL121324NICHD NIH HHS K12 HD051958
6 · The paper itself

Abstract

contextSugar overconsumption and chronic stress are growing health concerns because they both may increase the risk for obesity and its related diseases. Rodent studies suggest that sugar consumption may activate a glucocorticoid-metabolic-brain-negative feedback pathway, which may turn off the stress response and thereby reinforce habitual sugar overconsumption.

objectiveThe objective of the study was to test our hypothesized glucocorticoid-metabolic-brain model in women consuming beverages sweetened with either aspartame of sucrose.

designThis was a parallel-arm, double-masked diet intervention study.

settingThe study was conducted at the University of California, Davis, Clinical and Translational Science Center's Clinical Research Center and the University of California, Davis, Medical Center Imaging Research Center.

participantsNineteen women (age range 18-40 y) with a body mass index (range 20-34 kg/m(2)) who were a subgroup from a National Institutes of Health-funded investigation of 188 participants assigned to eight experimental groups.

interventionThe intervention consisted of sucrose- or aspartame-sweetened beverage consumption three times per day for 2 weeks.

main outcome measuresSalivary cortisol and regional brain responses to the Montreal Imaging Stress Task were measured.

resultsCompared with aspartame, sucrose consumption was associated with significantly higher activity in the left hippocampus (P = .001). Sucrose, but not aspartame, consumption associated with reduced (P = .024) stress-induced cortisol. The sucrose group also had a lower reactivity to naltrexone, significantly (P = .041) lower nausea, and a trend (P = .080) toward lower cortisol.

conclusionThese experimental findings support a metabolic-brain-negative feedback pathway that is affected by sugar and may make some people under stress more hooked on sugar and possibly more vulnerable to obesity and its related conditions.

Indexed as

BeveragesAdolescentAdultBrainDietary CarbohydratesEnergy IntakeFeeding BehaviorFemaleHumansHydrocortisoneMagnetic Resonance ImagingObesityStress, PsychologicalSubstance-Related DisordersSweetening AgentsWeight GainDietary CarbohydratesHydrocortisoneSweetening Agents

Identifiers

PMID25879513
PMCPMC4454811
OpenAlexW2125159096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.