ArticleVeterinary research2015
The oral and conjunctival microbiotas in cats with and without feline immunodeficiency virus infection.
Article in Veterinary research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- First Description of Oral Microbiota in Domestic Cats Affected by Oral Squamous Cell Carcinoma.Pathogens (Basel, Switzerland) · 2026Article
- Article
- The effect of topical antibiotic or antibiotic-corticosteroid treatment on the ocular surface microbiota of healthy horses.Frontiers in microbiology · 2025Article
- A Comparative Study on the Impact of FIV and FeLV Infection on the Ocular Microbiota in Persian Cats: Insights From Co-Infection and Single Infections.Veterinary medicine international · 2025Article
- Impacts of Antiretroviral Therapy on the Oral Microbiome and Periodontal Health of Feline Immunodeficiency Virus Positive Cats.bioRxiv : the preprint server for biology · 2024Article
- Incidence of Chlamydia spp., FIV, FeLV in Free-Roaming Cats in Slovakia.Veterinary medicine (Auckland, N.Z.) · 2024Article
- Polyhexamethylene guanidine hydrochloride as promising active ingredient for oral antiseptic products to eliminate microorganisms threatening the health of endangered wild cats: a comparative study with chlorhexidine digluconate.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- Metagenomic Analysis of DNA Viruses with Targeted Sequence Capture of Canine Lobular Orbital Adenomas and Normal Conjunctiva.Microorganisms · 2023Article
- Alterations of the bacterial ocular surface microbiome are found in both eyes of horses with unilateral ulcerative keratitis.PloS one · 2023Article
- Ocular Microbiome in a Group of Clinically Healthy Horses.Animals : an open access journal from MDPI · 2022Article
- Isolation and Identification ofVeterinary sciences · 2022Article
- Characterization of Oral Microbiota in Cats: Novel Insights on the Potential Role of Fungi in Feline Chronic Gingivostomatitis.Pathogens (Basel, Switzerland) · 2021Article
- Influence of the FIV Status and Chronic Gingivitis on Feline Oral Microbiota.Pathogens (Basel, Switzerland) · 2020Article
- Article
- Evaluation of the bacterial ocular surface microbiome in clinically normal cats before and after treatment with topical erythromycin.PloS one · 2019Article
- Article
- Article
- Applications of the FIV Model to Study HIV Pathogenesis.Viruses · 2018Review
- Stress and stability: applying the Anna Karenina principle to animal microbiomes.Nature microbiology · 2017Article
- Pathogenesis of oral FIV infection.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oral and conjunctival microbiotas likely play important roles in protection from opportunistic infections, while also being the source of potential pathogens. Yet, there has been limited investigation in cats, and the impact of comorbidities such as feline immunodeficiency virus (FIV) infection has not been reported. Oral and conjunctival swabs were collected from cats with FIV infection and FIV-uninfected controls, and subjected to 16S rRNA gene (V4) PCR and next generation sequencing. 9,249 OTUs were identified from conjunctival swabs, yet the most common 20 (0.22%) OTUs accounted for 76% of sequences. The two most abundant OTUs both belonged to Staphylococcus, and accounted for 37% of sequences. Cats with FIV infection had significantly lower relative abundances of Verrucomicrobia, Fibrobacteres, Spirochaetes, Bacteroidetes and Tenericutes, and a higher relative abundance of Deinococcus-Thermus. There were significant differences in both community membership (P = 0.006) and community structure (P = 0.02) between FIV-infected and FIV-uninfected cats. FIV-infected cats had significantly higher relative abundances of Fusobacteria and Actinobacteria in the oral cavity, and significantly higher relative abundances of several bacterial classes including Fusobacteria (0.022 vs 0.007, P = 0.006), Actinobacteria (0.017 vs 0.003, P = 0.003), Sphingobacteria (0.00015 vs 0.00003, P = 0.0013) and Flavobacteria (0.0073 vs 0.0034, P = 0.030). The feline conjunctival and oral microbiotas are complex polymicrobial communities but dominated by a limited number of genera. There is an apparent impact of FIV infection on various components of the microbiota, and assessment of the clinical relevance of these alterations in required.
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