ArticleNeural development2015
Formation of functional areas in the cerebral cortex is disrupted in a mouse model of autism spectrum disorder.
Article in Neural development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 57 citations in OpenAlex.
- Pathogenic O-GlcNAc dyshomeostasis is associated with cortical malformations and hyperactivity.eLife · 2026Article
- Fetal Cortical Layers and Midline Histological Alterations in the BTBR Mouse Model of Neurodevelopmental Disorders.Biology · 2026Article
- Domain-specific and sex-dependent behavioral alterations in the BTBR mouse model of autism.Frontiers in behavioral neuroscience · 2026Article
- Review
- Quantifying social distance using deep learning-based video analysis: results from the BTBR mouse model of autism.Frontiers in behavioral neuroscience · 2025Article
- Implications of draxin in neurological disorders.Frontiers in cell and developmental biology · 2025Review
- Analysis of structural variation among inbred mouse strains.BMC genomics · 2023Article
- Molecular Abnormalities in BTBR Mice and Their Relevance to Schizophrenia and Autism Spectrum Disorders: An Overview of Transcriptomic and Proteomic Studies.Biomedicines · 2023Article
- Mapping of morpho-electric features to molecular identity of cortical inhibitory neurons.PLoS computational biology · 2023Article
- Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies.Frontiers in neuroscience · 2023Review
- Circadian Responses to Light in the BTBR Mouse.Journal of biological rhythms · 2022Article
- Glass-brain mapping provides an adjunct tool for structural analysis in mouse models of neurodevelopmental disease.Neuroimage. Reports · 2021Article
- Phenotypic Characterization and Brain Structure Analysis of Calcium Channel Subunit αFrontiers in synaptic neuroscience · 2021Article
- Long-distance aberrant heterotopic connectivity in a mouse strain with a high incidence of callosal anomalies.NeuroImage · 2020Article
- Atypical visual processing in a mouse model of autism.Scientific reports · 2020Article
- Article
- Therapeutic Potential of Dihydropyridine Calcium Channel Blockers on Oxidative Injury Caused by Organophosphates in Cortex and Cerebellum: An In Vivo Study.Indian journal of clinical biochemistry : IJCB · 2020Article
- Precocious myelination in a mouse model of autism.Translational psychiatry · 2019Article
- Functional and structural asymmetry in primary motor cortex in Asperger syndrome: a navigated TMS and imaging study.Brain topography · 2019Article
- MultiLink Analysis: Brain Network Comparison via Sparse Connectivity Analysis.Scientific reports · 2019Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutism spectrum disorders (ASD) are a group of poorly understood behavioural disorders, which have increased in prevalence in the past two decades. Animal models offer the opportunity to understand the biological basis of these disorders. Studies comparing different mouse strains have identified the inbred BTBR T + tf/J (BTBR) strain as a mouse model of ASD based on its anti-social and repetitive behaviours. Adult BTBR mice have complete agenesis of the corpus callosum, reduced cortical thickness and changes in early neurogenesis. However, little is known about the development or ultimate organisation of cortical areas devoted to specific sensory and motor functions in these mice that may also contribute to their behavioural phenotype.
resultsIn this study, we performed diffusion tensor imaging and tractography, together with histological analyses to investigate the emergence of functional areas in the cerebral cortex and their connections in BTBR mice and age-matched C57Bl/6 control mice. We found evidence that neither the anterior commissure nor the hippocampal commissure compensate for the loss of callosal connections, indicating that no interhemispheric neocortical connectivity is present in BTBR mice. We also found that both the primary visual and somatosensory cortical areas are shifted medially in BTBR mice compared to controls and that cortical thickness is differentially altered in BTBR mice between cortical areas and throughout development.
conclusionsWe demonstrate that interhemispheric connectivity and cortical area formation are altered in an age- and region-specific manner in BTBR mice, which may contribute to the behavioural deficits previously observed in this strain. Some of these developmental patterns of change are also present in human ASD patients, and elucidating the aetiology driving cortical changes in BTBR mice may therefore help to increase our understanding of this disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.