ArticleBMC infectious diseases2015
Prevalence of latent tuberculosis infection and associated risk factors in an urban African setting.
Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 64 citations in OpenAlex.
- Prevalence of Latent Tuberculosis Infection in the Middle East and North Africa: A Systematic Review.Pulmonary medicine · 2021Pooled it
- Prevalence of Hepatitis C Virus in Tuberculosis Patients: A Systematic Review and Meta-Analysis.Ethiopian journal of health sciences · 2019Pooled it
- Risk Factors for Immunological Sensitization to Mycobacterium tuberculosis and Progression to Incident TB Disease Among HIV-uninfected Adults in a High Burden Setting.The Journal of infectious diseases · 2026Article
- Article
- Tissue-specific T cell profiles inFrontiers in tuberculosis · 2025Article
- Performance of a score to characterise adequate contact among the social network of persons with TB.IJTLD open · 2024Article
- Diverse interactions ofFrontiers in tuberculosis · 2024Review
- Prevalence and predictors of tuberculosis infection among people living with HIV in a high tuberculosis burden context.BMJ open respiratory research · 2023Article
- Management of Latent Tuberculosis Infection Based on T-SPOT.TB Assay in Patients with Hematological Malignancies.Mediterranean journal of hematology and infectious diseases · 2023Article
- Feasibility and acceptability of undertaking postmortem studies for tuberculosis medical research in a low income country.Frontiers in immunology · 2023Article
- Article
- Genetic and hormonal mechanisms underlying sex-specific immune responses in tuberculosis.Trends in immunology · 2022Review
- Mantoux test defaulters in rural population attending tertiary care hospital in a tuberculosis endemic area.Journal of family medicine and primary care · 2022Article
- Integrating interferon-gamma release assay testing into provision of tuberculosis preventive therapy is feasible in a tuberculosis high burden resource-limited setting: A mixed methods study.PLOS global public health · 2022Article
- Latent Tuberculosis Infection and Subclinical Coronary Atherosclerosis in Peru and Uganda.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Excess Risk of Tuberculosis Infection Among Extra-household Contacts of Tuberculosis Cases in an African City.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Association between tuberculosis in men and social network structure in Kampala, Uganda.BMC infectious diseases · 2021Article
- Heme oxygenase-1 and neopterin plasma/serum levels and their role in diagnosing active and latent TB among HIV/TB co-infected patients: a cross sectional study.BMC infectious diseases · 2021Article
- Tuberculosis Infection in Women of Reproductive Age: A Cross-sectional Study at Antenatal Care Clinics in an Ethiopian City.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Latent Tuberculosis Infection Status of Pregnant Women in Uganda Determined Using QuantiFERON TB Gold-Plus.Open forum infectious diseases · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundNearly one third of the world is infected with latent tuberculosis infection (LTBI) and a vast pool of individuals with LTBI persists in developing countries, posing a major barrier to global TB control. The aim of the present study was to determine the prevalence of LTBI and the associated risk factors among adults in Kampala, Uganda.
methodsWe performed a secondary analysis from a door-to-door cross-sectional survey of chronic cough conducted from January 2008 to June 2009. Urban residents of Rubaga community in Kampala aged 15 years and older who had received Tuberculin skin testing (TST) were included in the analysis. The primary outcome was LTBI defined as a TST with induration 10 mm or greater. Multivariable logistic regression analyses were used to assess the risk factors associated with LTBI.
resultsA total of 290 participants were tested with TST, 283 had their tests read and 7 didn't have the TST read because of failure to trace them within 48-72 hours. Of the participants with TST results, 68% were female, 75% were 15-34 years, 83% had attained at least 13 years of education, 12% were smokers, 50% were currently married, 57% left home for school or employment, 21% were HIV positive and 65% reported chronic cough of 2 weeks or longer. The overall prevalence of LTBI was 49% [95% CI 44-55] with some age-and sex-specific differences. On multivariable analysis, leaving home for school or employment, aOR = 1.72; [95%CI: 1.05, 2.81] and age 25-34, aOR = 1.94; [95%CI: 1.12, 3.38]; 35 years and older, aOR = 3.12; [95%CI: 1.65, 5.88] were significant risk factors of LTBI.
conclusionThe prevalence of LTBI was high in this urban African setting. Leaving home for school or employment and older age were factors significantly associated with LTBI in this setting. This suggests a potential role of expansion of one's social network outside the home and cumulative risk of exposure to TB with age in the acquisition of LTBI. Our results provide support for LTBI screening and preventive treatment programs of these sub-groups in order to enhance TB control.
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