SynthesisTheScientificWorldJournal2015
Low-level laser therapy in the treatment of recurrent aphthous ulcers: a systematic review.
Synthesis in TheScientificWorldJournal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The effectiveness of lower-level laser therapy on the treatment of minor recurrent aphthous ulcers: a systematic review and meta-analysis.Lasers in medical science · 2025Pooled it
- Effectiveness of low-level laser therapy in reducing pain score and healing time of recurrent aphthous stomatitis: a systematic review and meta-analysis.Systematic reviews · 2024Pooled it
- Effect of laser on pain relief and wound healing of recurrent aphthous stomatitis: a systematic review.Lasers in medical science · 2017Pooled it
- Evaluation of diode laser versus topical corticosteroid in management of Behcet's disease-associated oral ulcers: a randomized clinical trial.Clinical oral investigations · 2022Trial
- Antiproliferative effect of low-level laser/ photobiomodulation on gingival fibroblasts derived from calcium channel blocker-induced gingival overgrowth.Lasers in medical science · 2024Article
- Photobiomodulation Therapy in the Management of Late Complications After Facial Filling.Cureus · 2024Article
- Article
- Innovative Concepts and Recent Breakthrough for Engineered Graft and Constructs for Bone Regeneration: A Literature Systematic Review.Materials (Basel, Switzerland) · 2022Review
- Evaluation of Biological Activity of Different Wavelengths of Low-Level Laser Therapy on the Cancer Prostate Cell Line Compared With Cisplatin.Journal of lasers in medical sciences · 2021Article
- Low-level laser therapy in the treatment of recurrent aphthous stomatitis and oral lichen planus: a literature review.Postepy dermatologii i alergologii · 2020Review
- Low-Level Laser Therapy and Topical Medications for Treating Aphthous Ulcers: A Systematic Review.Journal of multidisciplinary healthcare · 2020Review
- Laser therapy for recurrent aphthous stomatitis: an overview.Clinical oral investigations · 2020Review
- A Randomized, Double-Blind, Placebo-Controlled Trial on Clinical Efficacy of Topical Agents in Reducing Pain and Frequency of Recurrent Aphthous Ulcers.The open dentistry journal · 2018Article
- Clinical effectiveness of low-level laser treatment on peripheral somatosensory neuropathy.Lasers in medical science · 2017Review
- Laser Surgery of Soft Tissue in Orthodontics: Review of the Clinical Trials.Journal of lasers in medical sciences · 2017Review
- Low-level laser therapy in 3D cell culture model using gingival fibroblasts.Lasers in medical science · 2016Article
- Effectiveness of Laser Therapy in the Management of Recurrent Aphthous Stomatitis: A Systematic Review.Scientifica · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recurrent aphthous ulcers (RAUs) are the most common lesion found in the oral cavity. There is no definitive cure for RAUs and current treatments are aimed at minimizing symptoms. Since low-level laser therapy (LLLT) modulates inflammatory responses, and promotes pain reduction and cellular biostimulation, LLLT can be suggested as an alternative treatment for RAUs. The literature concerning the potential of LLLT in the treatment of RAUs was evaluated. A systematic literature review identified 22 publications, of which only 2 studies were adopted. The eligibility criteria consisted of randomized controlled trials (RCTs). Both RCTs achieved significant results concerning LLLT and pain-level reductions and reduced healing times. Despite the variance in irradiation conditions applied in both studies, very similar wavelengths were adopted. There is accordingly strong evidence that wavelength plays an important role in RAU treatment. Taking into account the different parameters applied by selected RCTs, it is not possible to suggest that a specific protocol should be used. However, in light of the significant results found in both studies, LLLT can be suggested as an alternative for RAU treatment. Additional RCTs should be performed in order to reach a clinical protocol and better understand the application of LLLT in RAU treatment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.