ArticleJournal of immunology research2015
MBL2 genotypes and their associations with MBL levels and NICU morbidity in a cohort of Greek neonates.
Article in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of epidemiological studies.Orphanet journal of rare diseases · 2018Pooled it
- Clinical associations of complement-activating collectins, collectin-10, collectin-11 and mannose-binding lectin in preterm neonates.Frontiers in immunology · 2024Article
- Collectins and ficolins in neonatal health and disease.Frontiers in immunology · 2023Review
- MBL deficiency-causing B allele (rs1800450) as a risk factor for severe COVID-19.Immunobiology · 2021Article
- A SNaPshot Assay for Determination of the Mannose-Binding Lectin Gene Variants and an Algorithm for Calculation of Haplogenotype Combinations.Diagnostics (Basel, Switzerland) · 2021Article
- The association of mannose binding lectin genotype and immune response to Chlamydia pneumoniae: The Strong Heart Study.PloS one · 2019Article
- Stressful Newborn Memories: Pre-Conceptual,Frontiers in psychiatry · 2019Review
- Autosomal dominant mannose-binding lectin deficiency is associated with worse neurodevelopmental outcomes after cardiac surgery in infants.The Journal of thoracic and cardiovascular surgery · 2018Article
- Article
- Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants.PloS one · 2017Article
- Mannose-binding lectin gene polymorphism and its effect on short term outcomes in preterm infants.Jornal de pediatriaArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2 genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and enzyme-linked immunosorbent assay, respectively. NICU neonates displayed significantly lower MBL serum levels compared to healthy ones. MBL deficiency, defined as the low MBL2 expression group (XA/O and O/O), was significantly associated with an increased risk of respiratory morbidity, especially transient tachypnea of the newborn and respiratory distress syndrome (RDS). Moreover, an increase of 100 ng/mL of serum MBL levels decreases by 5% the risk of total respiratory morbidity and by 7% the risk of RDS, after correction for prematurity and sex and regardless of the presence of infections. Our study further supports the notion that neonates with MBL deficiency and low MBL serum levels at birth may be at higher risk of developing severe respiratory complications.
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