ArticlePerspectives in clinical research
Pattern of adverse drug reactions due to cancer chemotherapy in a tertiary care hospital in South India.
Article in Perspectives in clinical research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 47 citations in OpenAlex.
- Systematic review and meta-analysis of chemotherapy-induced adverse drug reactions among children with cancer in Africa.Infectious agents and cancer · 2025Review
- Adherence to chemotherapy and associated factors among adult patients with cancer in the Amhara region, Ethiopia, 2022.Discover oncology · 2025Article
- Observational
- Pharmacovigilance Practices by Healthcare Providers in Oncology: A Cross-Sectional Study.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Pattern of Adverse Drug Reactions Associated with the Use of Anticancer Drugs in an Oncology-Based Hospital of Nepal.JMA journal · 2022Article
- Frequency, nature, severity and preventability of adverse drug reactions arising from cancer chemotherapy in a teaching hospital.Journal of family medicine and primary care · 2020Article
- Serious adverse effects occurring after chemotherapy: A general cancer registry-based incidence survey.British journal of clinical pharmacology · 2020Article
- Improving medication safety in oncology care: impact of clinical pharmacy interventions on optimizing patient safety.International journal of clinical pharmacy · 2019Article
- Adverse drug reactions due to cancer chemotherapy in a tertiary care teaching hospital.Therapeutic advances in drug safety · 2017Article
- Assessment of drug therapy problems among patients with cervical cancer at Kenyatta National Hospital, Kenya.Gynecologic oncology research and practice · 2017Article
- Predictors of adverse drug reactions in geriatric patients: An exploratory study among cancer patients.South Asian journal of cancerArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStudies regarding pattern of adverse drug reactions (ADRs) in cancer chemotherapy patients are scarce in India. This study was conducted to evaluate the pattern of occurrence of ADRs due to cancer chemotherapy in hospitalized patients and to assess the causality, severity, predictability, and preventability of these reactions. MATERIALS AND
methodsThis was a retrospective, descriptive study and the occurrence and nature of ADR, suspected drug, duration of hospital stay and outcome were noted from case records. These ADRs were assessed for causality using both World Health Organization (WHO) causality assessment scale and Naranjo's algorithm. The severity and preventability of the reported reactions were assessed using modified Hartwig and Siegel scale and modified Schumock and Thornton scale respectively.
resultsFive hundred ADRs were recorded from 195 patients. Most common ADRs were infections (22.4%), nausea/vomiting (21.6%) and febrile neutropenia (13%). Platinum compounds, nitrogen mustards, taxanes, antibiotics and 5-fluorouracil were the most common drugs causing ADRs. WHO causality assessment scale showed 65% of the reactions to be "probable" and 35% to be "possible", while Naranjo's algorithm indicated that 65.6% of ADRs were "probable" and 34.4% were "possible". Modified Hartwig and Siegel scale showed most reactions (41.4%) to be of "moderate level 4(a)" severity, while 30.6% of reactions were of "mild level 1" severity. About 30.8% of the ADRs were "definitely preventable" according to the modified Schumock and Thornton scale.
conclusionADRs are most important causes of morbidity and mortality and increase the economic burden on patient and society. By careful ADR monitoring, their incidence can be decreased.
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