Evidence map›Paper›PMID 25878945›Full record

ArticlePlastic and reconstructive surgery. Global open2015

Characterization of a Murine Pressure Ulcer Model to Assess Efficacy of Adipose-derived Stromal Cells.

Amy L Strong, Annie C Bowles, Connor P MacCrimmon, Stephen J Lee, Trivia P Frazier, Adam J Katz, Barbara Gawronska-Kozak, Bruce A Bunnell, Jeffrey M Gimble

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plastic and reconstructive surgery. Global open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 27 citations in OpenAlex.

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  9. Experimental animal modelling for pressure injury: A systematic review.Journal of clinical orthopaedics and trauma · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Amy L StrongCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Annie C BowlesCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Connor P MacCrimmonCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Stephen J LeeCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Trivia P FrazierCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Adam J KatzCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Barbara Gawronska-KozakCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Bruce A BunnellCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Jeffrey M GimbleCenter for Stem Cell Research and Regenerative Medicine, Tulane University School of Medicine, New Orleans, La.; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Florida, Gainesville, Fla.; Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland; Department of Pharmacology, Tulane University School of Medicine, New Orleans, La.; LaCell LLC, New Orleans, La.; Department of Medicine, Tulane Health Sciences Center, New Orleans, La.; and Department of Surgery, Tulane Health Sciences Center, New Orleans, La.
Institute of Animal Reproduction and Food Research · PLTulane University · US

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH HHS P51 OD011104
6 · The paper itself

Abstract

backgroundAs the world's population lives longer, the number of individuals at risk for pressure ulcers will increase considerably in the coming decades. In developed countries, up to 18% of nursing home residents suffer from pressure ulcers and the resulting hospital costs can account for up to 4% of a nation's health care budget. Although full-thickness surgical skin wounds have been used as a model, preclinical rodent studies have demonstrated that repeated cycles of ischemia and reperfusion created by exposure to magnets most closely mimic the human pressure ulcer condition.

methodsThis study uses in vivo and in vitro quantitative parameters to characterize the temporal kinetics and histology of pressure ulcers in young, female C57BL/6 mice exposed to 2 or 3 ischemia-reperfusion cycles. This pressure ulcer model was validated further in studies examining the efficacy of adipose-derived stromal/stem cell administration.

resultsOptimal results were obtained with the 2-cycle model based on the wound size, histology, and gene expression profile of representative angiogenic and reparative messenger RNAs. When treated with adipose-derived stromal/stem cells, pressure ulcer wounds displayed a dose-dependent and significant acceleration in wound closure rates and improved tissue histology.

conclusionThese findings document the utility of this simplified preclinical model for the evaluation of novel tissue engineering and medical approaches to treat pressure ulcers in humans.

Identifiers

PMID25878945
PMCPMC4387156
OpenAlexW1970537321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.