ArticleThyroid research2015
Hypothyroidism and brain developmental players.
Article in Thyroid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 94 citations in OpenAlex.
- Effect of initial levothyroxine dose on neurodevelopmental and growth outcomes in children with congenital hypothyroidism.Frontiers in endocrinology · 2022Trial
- Plant-derived nutritional components in thyroid disease-related neuropsychiatric disorders: mechanistic insights and advances.Frontiers in nutrition · 2026Review
- Neurodevelopmental Disorders, Cognitive Function, and Quality of Life in Children with Congenital Hypothyroidism in a Portuguese PopulationJournal of clinical research in pediatric endocrinology · 2025Article
- Protective role of the ginsenoside Rg1 against methimazole-induced gestational hypothyroidism on reflexive behaviors, conditioned fear and cortical antioxidant levels in mice offspring.IBRO neuroscience reports · 2024Article
- Evaluating the progression to abnormal thyrotropin in euthyroid preconception women: a population-based study.Thyroid research · 2024Article
- Review
- Temporal hampering of thyroid hormone synthesis just before hatching impeded the filial imprinting in domestic chicks.Frontiers in physiology · 2023Article
- Nanoselenium improved learning, memory, and brain-derived neurotrophic factor and attenuated nitric oxide, and oxidative stress in the brain of juvenile hypothyroid rats.Metabolic brain disease · 2022Article
- Promoter methylation changes in the placenta involved in the relationship between prenatal depression and small for gestational age.BMC pregnancy and childbirth · 2022Article
- Relationship between thyroid hormones and central nervous system metabolism in physiological and pathological conditions.Pharmacological reports : PR · 2022Review
- A review of species differences in the control of, and response to, chemical-induced thyroid hormone perturbations leading to thyroid cancer.Archives of toxicology · 2021Review
- A Review of Medical Conditions and Behavioral Problems in Dogs and Cats.Animals : an open access journal from MDPI · 2019Review
- c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model.Journal of molecular histology · 2018Article
- Gestational age, not transient hyperthyrotropinemia impacts brain white matter diffusion tensor imaging in premature infants.Experimental and therapeutic medicine · 2018Article
- Influence of maternal thyroid hormones during gestation on fetal brain development.Neuroscience · 2017Review
- Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain.Neurochemical research · 2017Review
- Gestational Arsenic Trioxide Exposure Acts as a Developing Neuroendocrine-Disruptor by Downregulating Nrf2/PPARγ and Upregulating Caspase-3/NF-ĸB/Cox2/BAX/iNOS/ROS.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most of our knowledge on the mechanisms of thyroid hormone (TH) dependent brain development is based on clinical observations and animal studies of maternal/fetal hypothyroidism. THs play an essential role in brain development and hormone deficiency during critical phases in fetal life may lead to severe and permanent brain damage. Maternal hypothyroidism is considered the most common cause of fetal TH deficiency, but the problem may also arise in the fetus. In the case of congenital hypothyroidism due to defects in fetal thyroid gland development or hormone synthesis, clinical symptoms at birth are often mild as a result of compensatory maternal TH supply. TH transporters (THTs) and deiodinases (Ds) are important regulators of intracellular triiodothyronine (T3) availability and therefore contribute to the control of thyroid receptors (TRs)-dependent CNS development and early embryonic life. Defects in fetal THTs or Ds may have more impact on fetal brain since they can result in intracellular T3 deficiency despite sufficient maternal TH supply. One clear example is the recent discovery of mutations in the TH transporter (monocarboxylate transporter 8; MCT8) that could be linked to a syndrome of severe and non reversible psychomotor retardation. Even mild and transient changes in maternal TH levels can directly affect and alter the gene expression profile, and thus disturb fetal brain development. Animal studies are needed to increase our understanding of the exact role of THTs and Ds in prenatal brain development.
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