ArticleIranian journal of nursing and midwifery research
The effect of vitamin D on vaginal atrophy in postmenopausal women.
Article in Iranian journal of nursing and midwifery research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Determinants and Effects of Vitamin D Supplementation in Postmenopausal Women: A Systematic Review.Nutrients · 2023Pooled it
- Trial
- The effect of oxytocin vaginal gel on vaginal atrophy in postmenopausal women: a randomized controlled trial.BMC women's health · 2020Trial
- Relationship between vitamin D status and the vaginal microbiome during pregnancy.Journal of perinatology : official journal of the California Perinatal Association · 2019Trial
- The effect of vitamin D and E vaginal suppositories on tamoxifen-induced vaginal atrophy in women with breast cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Trial
- [Resolution of the national interdisciplinary council of experts "High-dose vitamin D (Devilam) in the practice of an obstetrician-gynecologist"].Problemy endokrinologii · 2024Article
- Effect of Vitamin D Level on Female Vaginitis in Xi'an, China.International journal of women's health · 2024Article
- Effect of Vitamin D on the Proliferation and Barrier of Atrophic Vaginal Epithelial Cells.Molecules (Basel, Switzerland) · 2023Article
- Therapeutic Effects of Vitamin D on Vaginal, Sexual, and Urological Functions in Postmenopausal Women.Nutrients · 2023Review
- Effect of vitamin D vaginal suppository on sexual functioning among postmenopausal women: A three-arm randomized controlled clinical trial.Obstetrics & gynecology science · 2023Article
- The effect of conjugated estrogens vaginal cream and a combined vaginal cream of vitamins D and E in the treatment of genitourinary syndrome.Journal of family medicine and primary care · 2023Article
- The role of vitamin D in menopausal women's health.Frontiers in physiology · 2023Review
- Vitamin D deficiency increases the risk of bacterial vaginosis during pregnancy: Evidence from a meta-analysis based on observational studies.Frontiers in nutrition · 2022Article
- A Review of Pharmacological Treatments for Vaginal Atrophy in Postmenopausal Women in Iran.Journal of menopausal medicine · 2020Review
- Comparison of Serum Vitamin D Levels in Relation to Bowel and Bladder Symptoms in Women with Vulvar Diseases.International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition · 2020Article
- Effect of Vitamin D on the Vaginal Health of Menopausal Women: A Systematic Review.Journal of menopausal medicine · 2019Review
- Clinical implications of vitamin D deficiency.Przeglad menopauzalny = Menopause review · 2015Article
- Role of Vitamin D in urogenital health of geriatric participants.Journal of mid-life healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMost of the women suffer from vaginal atrophy and dryness, and therefore, efficient and safe treatment is needed to improve vaginal lubrication. Vitamin D has several important functions which may be effective in proliferation and repair of the epithelial tissue. This study aimed to evaluate the effect of vitamin D vaginal suppositories on maturation index, pH, and dryness in postmenopausal women. MATERIALS AND
methodsWomen were enrolled in this double-blind clinical trial, in whom menopause occurred at least one year ago. Those women who had an abnormal Papanicolaou smear, had undergone hormonal treatment, or have had vaginal infection in the previous year were excluded. Forty-four women who found eligible were randomized into two equal groups, the treatment and control groups, which received vitamin D and placebo vaginal suppository daily for 8 weeks, respectively. Vaginal pH and maturation value were measured at the beginning and end of the study. Pain, dryness, and paleness were assessed before treatment and at the end of the 2, 4, and 8 weeks of treatment.
resultsIn the treatment group, the number (Mean ± SD) of superficial cells increased (69.76 ± 12.4) and vaginal pH decreased (1.42 ± 0.67) significantly compared to the control group after 56 days. The mean pain significantly reduced after 8 weeks in the treatment group (1.23 ± 0.53) compared to the control group 1.95 ± 0.74 (P < 0.001). The mean of dryness and paleness reduced significantly in the treatment group versus control at 56 days.
conclusionsVitamin D is effective in improving the maturation index and decreased the pH and dryness of the vaginal atrophy due to menopause.
Indexed as
Identifiers
25878698PMC4387645W1752639748What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.