ArticlePakistan journal of medical sciences
Effect of smoking on serum xanthine oxidase, malondialdehyde, ascorbic acid and α-tocopherol levels in healthy male subjects.
Article in Pakistan journal of medical sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Association between smoking and gout: a meta-analysis.Clinical rheumatology · 2018Pooled it
- Serum xanthine oxidoreductase and oxidative stress are associated with bladder cancer: a case-control study from Jordan.Journal of applied biomedicine · 2025Article
- Maternal Electronic Cigarette Inhalation Exposure During Gestation: Impacts on Prolactin and Xanthine Oxidase.Cardiovascular toxicology · 2025Article
- The Dual Role of Oxidative Stress in Atherosclerosis and Coronary Artery Disease: Pathological Mechanisms and Diagnostic Potential.Antioxidants (Basel, Switzerland) · 2025Review
- Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products-A Narrative Review.International journal of molecular sciences · 2025Review
- The association between smoking and the occurrence of hyperuricemia: A retrospective cohort study.Tobacco induced diseases · 2025Article
- Modulation of cigarette smoke induced alterations by aqueous Ocimum sanctum leaf extract in pulmonary tissue of rodents.Scientific reports · 2023Article
- Investigating the Effect of Cigarette Smoking on Serum Uric Acid Levels in Multiple Sclerosis Patients: A Cross Sectional Study.Brain sciences · 2023Article
- Monocyte to high-density lipoprotein cholesterol ratio and serum uric acid in Chinese adults: a cross-sectional study.BMC endocrine disorders · 2022Article
- Semi-automated NMR Pipeline for Environmental Exposures: New Insights on the Metabolomics of Smokers versus Non-smokers.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2021Article
- Effect of dietary supplementation of nanocurcumin on oxidant stability of broiler chicken breast meat infected withVeterinary research forum : an international quarterly journal · 2020Article
- Plasma xanthine oxidoreductase activity in patients with decompensated acute heart failure requiring intensive care.ESC heart failure · 2019Article
- The Effectiveness of Vitamin E Treatment in Alzheimer's Disease.International journal of molecular sciences · 2019Review
- Observational
- Vitamin E and Alzheimer's disease: what do we know so far?Clinical interventions in aging · 2019Review
- 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine adducts of workers exposed to asbestos fibers.Toxicology letters · 2017Article
- Predicting disease onset in clinically healthy people.Interdisciplinary toxicology · 2016Review
- Complexity of vitamin E metabolism.World journal of biological chemistry · 2016Review
- Pathophysiology and Medical Treatment of Carotid Artery Stenosis.The International journal of angiology : official publication of the International College of Angiology, Inc · 2015Article
- Study on genotoxicity, oxidative stress biomarkers and clinical symptoms in workers of an asbestos-cement factory.EXCLI journal · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the effect of smoking on serum xanthine oxidase, malondialdehyde, α- tocopherol and ascorbic acid levels in healthy adult male subjects.
methodsThis cross-sectional comparative study was carried out at Isra University Hyderabad from July 2012 to December 2012. One hundred and twenty apparently healthy adult male subjects (60 smokers and 60 non-smokers) included in present study, were recruited from Jaindal kot, a small village located midway between Hyderabad and Matiari. Serum samples from smokers and non-smokers were analyzed for xanthine oxidase and malondialdehyde levels by standard kit methods, while for ascorbic acid and alpha- tocopherol by spectrophotometric methods.
resultsThe mean xanthine oxidase and malondialdehyde levels measured in healthy smokers were 0.30±0.05 mg/dl and 37.50±4.05 µmoles/l respectively as against 0.25±0.04 mg/dl and 19.86±2.21µmoles/l in non-smokers. Both xanthine oxidase and malondialdehyde levels were significantly (p<0.001) raised in healthy smokers than in non-smokers. Likewise, mean vitamin E and vitamin C levels were respectively 0.69±0.37 mg/dl and 0.80±0.16 mg/dl in healthy smokers compared to 1.14±0.43 mg/dl and 1.22±0.29 mg/dl in non-smokers. The concentrations of both these vitamins were significantly (p<0.001) lower in smokers than in non-smokers.
conclusionThe results of present study demonstrate that smoking had significantly increased xanthine oxidase and malondialdehyde levels and decreased vitamins C and E (antioxidants) levels. These findings suggest that smokers have to take additional amounts of vitamins C and E in order to avoid deleterious effects of smoking on their health.
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