Evidence map›Paper›PMID 25878400›Full record

ReviewMediators of inflammation2015

The utility of iron chelators in the management of inflammatory disorders.

C Lehmann, S Islam, S Jarosch, J Zhou, D Hoskin, A Greenshields, N Al-Banna, N Sharawy, A Sczcesniak, M Kelly and 3 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Mediators of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2026
    Pooled it
  2. Article
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  16. SARS-CoV-2 Neuronal Invasion and Complications: Potential Mechanisms and Therapeutic Approaches.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  17. Article
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  19. The Leaf Extract ofOxidative medicine and cellular longevity · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 3 countries.

C LehmannDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5 ; Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
S IslamDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Pharmacy, East West University, Plot No. A/2, Jahurul Islam City, Aftabnagar, Dhaka 1219, Bangladesh.
S JaroschDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
J ZhouDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5.
D HoskinDepartment of Microbiology and Immunology, Dalhousie University, 5850 College Street, Halifax, NS, Canada B3H 1X5 ; Department of Pathology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
A GreenshieldsDepartment of Pathology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
N Al-BannaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
N SharawyDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Physiology, Faculty of Medicine, Cairo University, 1 Al-Saray St., Cairo 11559, Egypt.
A SczcesniakDepartment of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
M KellyDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5 ; Department of Pharmacology, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
K WafaDepartment of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, 5850 College St., Halifax, NS, Canada B3H 1X5.
W CheliakChelation Partners Inc., 1411 Oxford St., Halifax, NS, Canada B3H 3Z1.
B HolbeinChelation Partners Inc., 1411 Oxford St., Halifax, NS, Canada B3H 3Z1.
Dalhousie University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.

Indexed as

AnimalsFibrosisHemochromatosisHumansInflammationIronIron Chelating AgentsKidneyNeoplasmsReactive Oxygen SpeciesSystemic Inflammatory Response SyndromeIronIron Chelating AgentsReactive Oxygen Species

Identifiers

PMID25878400
PMCPMC4386698
OpenAlexW1974910643

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.