Evidence map›Paper›PMID 25878381›Full record

ArticleIndian journal of pharmacology

Chemical genetic effects of Sargassum wightii during embryonic development in zebrafish.

Rajaretinam Rajesh Kannan, Appadurai Muthamil Iniyan, Samuel Gnana Prakash Vincent

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Rajaretinam Rajesh KannanMolecular Nanomedicine and Neuroscience Research Unit, Centre for Nanoscience and Nanotechnology, Sathyabama University, Chennai, India ; International Centre for Nanobiotechnology, Centre for Marine Science and Technology Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari, Tamil Nadu, India.
Appadurai Muthamil IniyanInternational Centre for Nanobiotechnology, Centre for Marine Science and Technology Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari, Tamil Nadu, India.
Samuel Gnana Prakash VincentInternational Centre for Nanobiotechnology, Centre for Marine Science and Technology Manonmaniam Sundaranar University, Rajakkamangalam, Kanyakumari, Tamil Nadu, India.
Manonmaniam Sundaranar University · INSathyabama Institute of Science and Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePhenotype based small molecule discovery is a category of chemical genetic study. The aim of this study was to observe the phytochemical based genetic effects of Sargassum wightii during organogenesis in embryonic zebrafish. MATERIALS AND

methodsThe phytomolecules from S. wightii were extracted using organic solvents and treated with the 24 h old developing zebrafish embryos. The active extract was partially purified by column chromatography, C18 Sep-Pak column and reversed-phase high-performance liquid chromatography.

resultsInitially, cardiac bulging was found in 2 dpf to 3 dpf (days post fertilization), then bradycardia and tubular heart were observed in the next 8 h, which also showed the reduction in the heart beat rates. The phenotypic mutation effects of bre, has, dou yan, heg and you were observed in the 3 dpf and 4 dpf of the extract treated zebrafish embryos.

conclusionsThis study demonstrated that the phytomolecules from S. wightii exhibited potential molecular switches on the developmental process, which might have significant role in understanding the development based chemical genetic studies in zebrafish.

Indexed as

Embryonic DevelopmentAbnormalities, Drug-InducedAnimalsBiological ProductsEmbryo, NonmammalianMutationPericardiumSargassumZebrafishBiological ProductsChemical geneticsphytomoleculessmall molecules screeningtubular heartzebrafish

Identifiers

PMID25878381
PMCPMC4386130
OpenAlexW2013311557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.