ArticleJournal of clinical microbiology2015
Implementation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry in Routine Clinical Laboratories Improves Identification of Coagulase-Negative Staphylococci and Reveals the Pathogenic Role of Staphylococcus lugdunensis.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Native Valve Infective Endocarditis Caused by Staphylococcus condimenti: First Case Reported.JACC. Case reports · 2026Article
- Clinical presentation, treatment, and antimicrobial susceptibility of 155 sequentialMicrobiology spectrum · 2025Article
- Comparison ofInternational journal of molecular sciences · 2025Article
- Clinical Significance and Microbiological Characteristics ofJournal of clinical medicine · 2024Article
- Direct sub-atmospheric pressure ionization mass spectrometry: Evaporation/sublimation-driven ionization is amazing, fundamentally, and practically.Journal of mass spectrometry : JMS · 2024Review
- From Obscurity To Spotlight: Staphylococcus lugdunensis-Induced Infective Endocarditis, a Profound Case Unraveling.Cureus · 2023Article
- May Staphylococcus lugdunensis Be an Etiological Factor of Chronic Maxillary Sinuses Infection?International journal of molecular sciences · 2022Article
- Importance ofThe Journal of international medical research · 2022Article
- Knowledge, Attitude and Practice RegardingInfectious disease reports · 2022Review
- Genome-Scale Metabolic Modelling Approach to Understand the Metabolism of the Opportunistic Human PathogenMetabolites · 2022Article
- Article
- Staphylococcus lugdunensis: a Skin Commensal with Invasive Pathogenic Potential.Clinical microbiology reviews · 2021Review
- Comparative Genomic Analyses Reveal Potential Factors Responsible for the ST6 Oxacillin-ResistantFrontiers in microbiology · 2021Article
- Article
- Evaluation of the Autof MS1000 mass spectrometer in the identification of clinical isolates.BMC microbiology · 2020Article
- Current Status of Matrix-Assisted Laser Desorption/Ionization-Time-of-Flight Mass Spectrometry (MALDI-TOF MS) in Clinical Diagnostic Microbiology.Molecules (Basel, Switzerland) · 2020Review
- Coagulase-negative staphylococci in outpatient routines: the implications of switching from CLSI to BrCAST/EUCAST guidelines.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2020Article
- Review
- Evaluation of penicillin G susceptibility testing methods for Staphylococcus lugdunensis.The Journal of antimicrobial chemotherapy · 2020Article
- Coagulase-Negative Staphylococci Pathogenomics.International journal of molecular sciences · 2019Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The use of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) for staphylococcal identification is now considered routine in laboratories compared with the conventional phenotypical methods previously used. We verified its microbiological relevance for identifying the main species of coagulase-negative staphylococci (CoNS) by randomly selecting 50 isolates. From 1 January 2007 to 31 August 2008, 12,479 staphylococci were isolated with phenotypic methods, of which 4,594 were identified as Staphylococcus aureus and 7,885 were coagulase negative staphylococci. Using MALDI-TOF MS from 1 January 2011 to 31 August 2012, 14,913 staphylococci were identified, with 5,066 as S. aureus and 9,847 as CoNS. MALDI-TOF MS allowed the identification of approximately 85% of the CoNS strains, whereas only 14% of the CoNS strains were identified to the species level with phenotypic methods because they were often considered contaminants. Furthermore, the use of MALDI-TOF MS revealed the occurrence of recently characterized Staphylococcus species, such as S. pettenkoferi, S. condimenti, and S. piscifermentans. Microbiological relevance analysis further revealed that some species displayed a high rate of microbiological significance, i.e., 40% of the S. lugdunensis strains included in the analysis were associated with infection risk. This retrospective microbiological study confirms the role of MALDI-TOF MS in clinical settings for the identification of staphylococci with clinical consequences. The species distribution reveals the occurrence of the recently identified species S. pettenkoferi and putative virulent species, including S. lugdunensis.
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