ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2015
Microsecond-scale timing precision in rodent trigeminal primary afferents.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Pre-neuronal processing of haptic sensory cues via dispersive high-frequency vibrational modes.Scientific reports · 2023Article
- Reducing Merkel cell activity in the whisker follicle disrupts cortical encoding of whisker movement amplitude and velocity.IBRO neuroscience reports · 2022Article
- Of mice and monkeys: Somatosensory processing in two prominent animal models.Progress in neurobiology · 2021Review
- Sequence Learning Induces Selectivity to Multiple Task Parameters in Mouse Somatosensory Cortex.Current biology : CB · 2021Article
- The Cellular and Mechanical Basis for Response Characteristics of Identified Primary Afferents in the Rat Vibrissal System.Current biology : CB · 2020Article
- Reconfigurable nanophotonic silicon probes for sub-millisecond deep-brain optical stimulation.Nature biomedical engineering · 2020Article
- A system for tracking whisker kinematics and whisker shape in three dimensions.PLoS computational biology · 2020Article
- Prediction of Choice from Competing Mechanosensory and Choice-Memory Cues during Active Tactile Decision Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Generalization of Object Localization From Whiskers to Other Body Parts in Freely Moving Rats.Frontiers in integrative neuroscience · 2019Article
- Neural timing of stimulus events with microsecond precision.PLoS biology · 2018Article
- A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices.Cell reports · 2018Article
- Dynamic cues for whisker-based object localization: An analytical solution to vibration during active whisker touch.PLoS computational biology · 2018Article
- Vibrissa sensory neurons: Linking distinct morphology to specific physiology and function.Neuroscience · 2018Review
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- High-velocity stimulation evokes "dense" population response in layer 2/3 vibrissal cortex.Journal of neurophysiology · 2017Article
- Thalamic state control of cortical paired-pulse dynamics.Journal of neurophysiology · 2017Article
- Edge orientation signals in tactile afferents of macaques.Journal of neurophysiology · 2016Article
- Whisking mechanics and active sensing.Current opinion in neurobiology · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000°/s, so we delivered an ultrafast "ping" (>50,000°/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 μs; 29% of neurons had spike jitter < 10 μs. These results indicate that the input stage of the trigeminal pathway has extraordinary spike-timing precision and very high potential information capacity. This timing precision ranks among the highest in biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.