ArticleJournal of neurophysiology2015
Differential fiber-specific block of nerve conduction in mammalian peripheral nerves using kilohertz electrical stimulation.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 87 citations in OpenAlex.
- Suppression of visceral nociception by C-fiber transmission block using temporal interference sinusoidal stimulation.Pain reports · 2026Article
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Fascicle-selective kilohertz-frequency neural conduction block with longitudinal intrafascicular electrodes.Journal of neural engineering · 2025Article
- Membrane depolarization mediates both the inhibition of neural activity and cell-type-differences in response to high-frequency stimulation.Communications biology · 2024Article
- Using neural biomarkers to personalize dosing of vagus nerve stimulation.Bioelectronic medicine · 2024Article
- Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain.Journal of neural engineering · 2024Article
- Blocking Aδ- and C-fiber neural transmission by sub-kilohertz peripheral nerve stimulation.Frontiers in neuroscience · 2024Article
- Selective Infrared Neural Inhibition Can Be Reproduced by Resistive Heating.Neuromodulation : journal of the International Neuromodulation Society · 2023Article
- Stimulation parameters for directional vagus nerve stimulation.Bioelectronic medicine · 2023Article
- High frequency alternating current neurostimulation decreases nocifensive behavior in a disc herniation model of lumbar radiculopathy.Bioelectronic medicine · 2023Article
- Kilohertz-frequency interferential current induces hypoalgesic effects more comfortably than TENS.Scientific reports · 2023Article
- Vagus Nerve Stimulation and Its Cardioprotective Abilities: A Systematic Review.Journal of clinical medicine · 2023Review
- A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity.Patterns (New York, N.Y.) · 2022Article
- Effects of waveform shape and electrode material on KiloHertz frequency alternating current block of mammalian peripheral nerve.Bioelectronic medicine · 2022Article
- Blood glucose modulation and safety of efferent vagus nerve stimulation in a type 2 diabetic rat model.Physiological reports · 2022Article
- Effect of Percutaneous Electric Stimulation with High-Frequency Alternating Currents on the Sensory-Motor System of Healthy Volunteers: A Double-Blind Randomized Controlled Study.Journal of clinical medicine · 2022Article
- Use of an invertebrate animal model (Frontiers in neuroscience · 2022Review
- A Reversible Low Frequency Alternating Current Nerve Conduction Block Applied to Mammalian Autonomic Nerves.Sensors (Basel, Switzerland) · 2021Article
- In-vivo application of low frequency alternating currents on porcine cervical vagus nerve evokes reversible nerve conduction block.Bioelectronic medicine · 2021Article
- Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.Scientific reports · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Kilohertz electrical stimulation (KES) has been shown to induce repeatable and reversible nerve conduction block in animal models. In this study, we characterized the ability of KES stimuli to selectively block specific components of stimulated nerve activity using in vivo preparations of the rat sciatic and vagus nerves. KES stimuli in the frequency range of 5-70 kHz and amplitudes of 0.1-3.0 mA were applied. Compound action potentials were evoked using either electrical or sensory stimulation, and block of components was assessed through direct nerve recordings and muscle force measurements. Distinct observable components of the compound action potential had unique conduction block thresholds as a function of frequency of KES. The fast component, which includes motor activity, had a monotonically increasing block threshold as a function of the KES frequency. The slow component, which includes sensory activity, showed a nonmonotonic block threshold relationship with increasing KES frequency. The distinct trends with frequency of the two components enabled selective block of one component with an appropriate choice of frequency and amplitude. These trends in threshold of the two components were similar when studying electrical stimulation and responses of the sciatic nerve, electrical stimulation and responses of the vagus nerve, and sensorimotor stimulation and responses of the sciatic nerve. This differential blocking effect of KES on specific fibers can extend the applications of KES conduction block to selective block and stimulation of neural signals for neuromodulation as well as selective control of neural circuits underlying sensorimotor function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.