ArticleJournal of the Royal Society, Interface2015
Fluid flow and sperm guidance: a simulation study of hydrodynamic sperm rheotaxis.
Article in Journal of the Royal Society, Interface, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Generalized Taylor dispersion of chiral microswimmers.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Physics of microbial taxis and behaviours in response to various physical stimuli.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Review
- Swimming by Spinning: Spinning-Top Type Rotations Regularize Sperm Swimming Into Persistently Progressive Paths in 3D.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Microfluidics-A novel technique for high-quality sperm selection for greater ART outcomes.FASEB bioAdvances · 2024Review
- Fluid flow reconstruction around a free-swimming sperm in 3D.bioRxiv : the preprint server for biology · 2024Article
- An assessment tool for computer-assisted semen analysis (CASA) algorithms.Scientific reports · 2022Article
- Separation of motile human sperms in a T-shaped sealed microchannel.Biomedical engineering letters · 2022Article
- Hydrodynamic Behavior of Self-Propelled Particles in a Simple Shear Flow.Entropy (Basel, Switzerland) · 2022Article
- Simple dynamics underlying the survival behaviors of ciliates.Biophysics and physicobiology · 2022Article
- Migration of active filaments under Poiseuille flow in a microcapillary tube.The European physical journal. E, Soft matter · 2021Article
- Near-wall rheotaxis of the ciliateScience advances · 2021Article
- Driving a Microswimmer with Wall-Induced Flow.Micromachines · 2021Article
- Control and controllability of microswimmers by a shearing flow.Royal Society open science · 2021Article
- Modelling Motility: The Mathematics of Spermatozoa.Frontiers in cell and developmental biology · 2021Review
- Swimming of Spermatozoa in a Maxwell Fluid.Micromachines · 2019Article
- Response of monoflagellate pullers to a shearing flow: A simulation study of microswimmer guidance.Physical review. E · 2018Article
- Microfluidics for sperm analysis and selection.Nature reviews. Urology · 2017Review
- The mechanics clarifying counterclockwise rotation in most IVF eggs in mice.Scientific reports · 2017Article
- Mechanical tuning of mammalian sperm behaviour by hyperactivation, rheology and substrate adhesion: a numerical exploration.Journal of the Royal Society, Interface · 2016Article
- Human sperm rheotaxis: a passive physical process.Scientific reports · 2016Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
How does a sperm find its way? The study of guidance cues has fascinated sperm biologists and in particular the prospect of rheotaxis, that is a fluid flow orienting the direction of sperm swimming, has been the subject of extensive recent study, as readily motivated by the prospect that such guidance may be active in the mammalian female reproductive tract. For instance, it has been hypothesized that helical sperm flagellar beating is necessary for such guidance, whereas there is an extensive diversity of flagellar beating patterns, with planar sperm beating readily observed in human cells for example. In particular, such cells will not be guided by fluid flow according to hypothesized mechanisms for rheotaxis presented thus far. Here, using simulation methods, we investigate rheotaxis for a wide range of flagellar beat patterns. Providing the virtual sperm firstly does not possess a tightly circling trajectory in the absence of a background flow and secondly, remains within a region of low shear to prevent being washed away by the background flow, rheotaxis is generally observed with the sperm swimming into the flow together with a possible transverse velocity. Tight circling sperm motility, as observed in select hyperactivated sperm and CatSper mutants, is predicted to disrupt the rheotactic response, whereas confinement to low shear regions generally requires boundary accumulation, thus introducing subtleties in the relationship between rheotactic behaviours and the flagellar waveform and sperm characteristics. Nonetheless, such predictions suggest such rheotactic guidance may be more common and robust than previously thought, and we document simple criteria for the presence of rheotaxis that are consistent with our simulations and understanding, as well as reported observations to date.
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