ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2015
Recruitment and Screening for the Testosterone Trials.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Recruitment strategies in randomised controlled trials of men aged 50 years and older: a systematic review.BMJ open · 2019Pooled it
- Recruitment and Screening Methods in Alzheimer's Disease Research: The FIT-AD Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Trial
- The Enabling Reduction of Low-Grade Inflammation in Seniors (ENRGISE) Pilot Study: Screening Methods and Recruitment Results.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Trial
- Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial.JAMA internal medicine · 2017Trial
- Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial.JAMA internal medicine · 2017Trial
- Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone.JAMA · 2017Trial
- Testosterone Treatment and Sexual Function in Older Men With Low Testosterone Levels.The Journal of clinical endocrinology and metabolism · 2016Trial
- The Cardiovascular Trial of the Testosterone Trials: rationale, design, and baseline data of a clinical trial using computed tomographic imaging to assess the progression of coronary atherosclerosis.Coronary artery disease · 2016Trial
- Effects of Testosterone Treatment in Older Men.The New England journal of medicine · 2016Trial
- The aporetic dialogs of Modena on gender differences: Is it all about testosterone? Episode III: Mathematics.Andrology · 2026Review
- Prostate-Specific Antigen Levels During Testosterone Treatment of Hypogonadal Older Men: Data from a Controlled Trial.The Journal of clinical endocrinology and metabolism · 2019Article
- Observational
- Testosterone Replacement in Men with Age-Related Low Testosterone: What Did We Learn From The Testosterone Trials?Current opinion in endocrine and metabolic research · 2019Article
- Effect of testosterone replacement on measures of mobility in older men with mobility limitation and low testosterone concentrations: secondary analyses of the Testosterone Trials.The lancet. Diabetes & endocrinology · 2018Article
- Screening, Recruitment, and Baseline Characteristics for the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2018Article
- Lessons From the Testosterone Trials.Endocrine reviews · 2018Article
- A summary of the controversy surrounding off-label medications in men's health.Translational andrology and urology · 2016Review
- Battle of the sex steroids in the male skeleton: and the winner is....The Journal of clinical investigation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 15 institutions in 1 country.
Funding
Abstract
backgroundWe describe the recruitment of men for The Testosterone (T) Trials, which were designed to determine the efficacy of T treatment.
methodsMen were eligible if they were ≥65 years, had an average of two morning total T values <275 ng/dL with neither value >300 ng/mL, and had symptoms and objective evidence of mobility limitation, sexual dysfunction, and/or low vitality. Men had to be eligible for and enroll in at least one of these three main trials (physical function, sexual function, vitality).
resultsMen were recruited primarily through mass mailings in 12 U.S. communities: 82% of men who contacted the sites did so in response to mailings. Men who responded were screened by telephone to ascertain eligibility. Of 51,085 telephone screens, 53.5% were eligible for further screening. Of 23,889 initial screening visits (SV1), 2,781 (11.6%) men were eligible for the second screening visit (SV2), which 2,261 (81.3%) completed. At SV2, 931 (41.2%) men met the criteria for one or more trials, the T level criterion and had no other exclusions. Of these, 790 (84.6%) were randomized; 99 (12.5%) in all three trials and 348 (44%) in two trials. Their mean age was 72 years and mean body mass index (BMI) was 31.0 kg/m(2). Mean (standard deviation) total T (ng/dL) was 212.0 (40.0).
conclusionDespite the telephone screening to enrollment ratio of 65 to 1, we met the recruitment goals for each trial. Recruitment of symptomatic older men with low testosterone levels is difficult but feasible.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.