ArticleArchives of virology2015
Evolutionary trends of European bat lyssavirus type 2 including genetic characterization of Finnish strains of human and bat origin 24 years apart.
Article in Archives of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Phylogeographic Aspects of Bat Lyssaviruses in Europe: A Review.Pathogens (Basel, Switzerland) · 2023Review
- Review
- Detection of potentially novel paramyxovirus and coronavirus viral RNA in bats and rats in the Mekong Delta region of southern Viet Nam.Zoonoses and public health · 2018Article
- Molecular Epidemiology and Evolution of European Bat Lyssavirus 2.International journal of molecular sciences · 2018Review
- Second case of European bat lyssavirus type 2 detected in a Daubenton's bat in Finland.Acta veterinaria Scandinavica · 2017Article
- First detection of European bat lyssavirus type 2 (EBLV-2) in Norway.BMC veterinary research · 2017Article
- Clinical and biological insights from viral genome sequencing.Nature reviews. Microbiology · 2017Review
- High prevalence and diversity of viruses of the subfamily Gammaherpesvirinae, family Herpesviridae, in fecal specimens from bats of different species in southern China.Archives of virology · 2016Article
- Lyssavirus-reactive antibodies in Swedish bats.Infection ecology & epidemiology · 2016Article
Corrections and comments
- Erratum issuedErratum to: Evolutionary trends of European bat lyssavirus type 2 including genetic characterization of Finnish strains of human and bat origin 24 years apart.2015 · Miia, Jakava-Viljanen [corrected to Jakava-Viljanen, Miia]; Tiina, Nokireki [corrected to Nokireki, Tiina]; Tarja, Sironen [corrected to Sironen, Tarja]; Olli, Vapalahti [corrected to Vapalahti, Olli]; Liisa, Sihvonen [corrected to Sihvonen, Liisa]; Anita,
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among other Lyssaviruses, Daubenton's and pond-bat-related European bat lyssavirus type 2 (EBLV-2) can cause human rabies. To investigate the diversity and evolutionary trends of EBLV-2, complete genome sequences of two Finnish isolates were analysed. One originated from a human case in 1985, and the other originated from a bat in 2009. The overall nucleotide and deduced amino acid sequence identity of the two Finnish isolates were high, as well as the similarity to fully sequenced EBLV-2 strains originating from the UK and the Netherlands. In phylogenetic analysis, the EBLV-2 strains formed a monophyletic group that was separate from other bat-type lyssaviruses, with significant support. EBLV-2 shared the most recent common ancestry with Bokeloh bat lyssavirus (BBLV) and Khujan virus (KHUV). EBLV-2 showed limited diversity compared to RABV and appears to be well adapted to its host bat species. The slow tempo of viral evolution was evident in the estimations of divergence times for EBLV-2: the current diversity was estimated to have built up during the last 2000 years, and EBLV-2 diverged from KHUV about 8000 years ago. In a phylogenetic tree of partial N gene sequences, the Finnish EBLV-2 strains clustered with strains from Central Europe, supporting the hypothesis that EBLV-2 circulating in Finland might have a Central European origin. The Finnish EBLV-2 strains and a Swiss strain were estimated to have diverged from other EBLV-2 strains during the last 1000 years, and the two Finnish strains appear to have evolved from a common ancestor during the last 200 years.
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