Evidence map›Paper›PMID 25877866›Full record

ArticleThe Laryngoscope2015

Self-reported Tobacco use does not correlate with carcinogen exposure in smokers with head and neck cancer.

Samir S Khariwala, Steven G Carmella, Irina Stepanov, Dipankar Bandyopadhyay, Heather H Nelson, Bevan Yueh, Dorothy K Hatsukami, Stephen S Hecht

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Does Quitting Smoking Make a Difference Among Newly Diagnosed Head and Neck Cancer Patients?Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016
    Observational
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Samir S KhariwalaDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota.
Steven G CarmellaMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Irina StepanovMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Dipankar BandyopadhyayMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Heather H NelsonMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Bevan YuehDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota.
Dorothy K HatsukamiMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, U.S.A.
Stephen S HechtMasonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, U.S.A.
University of Minnesota · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI HEATHER Hammond NELSON · 1998 to 2026
$100.4M
Tobacco carcinogens as markers of exposure, carcinogenesis and risk in oral canceK23DE023572 · NIDCR · UNIVERSITY OF MINNESOTA · PI KHARIWALA, SAMIR S · 2013 to 2017
$681k
NCI NIH HHS P30 CA077598NIDCR NIH HHS K23 DE023572
6 · The paper itself

Abstract

objectives/hypothesisHead and neck squamous cell carcinoma (HNSCC) is strongly associated with tobacco use. We sought to examine the relationship between self-reported tobacco use and the level of urinary tobacco carcinogen metabolites in a cohort of patients with HNSCC. STUDY

designCross-sectional analysis.

methodsEighty-four cigarette smokers with head and neck cancer completed tobacco and alcohol use questionnaires, and the following urinary tobacco metabolites were quantified: 1-hydroxypyrene (1-HOP), N'-nitrosonornicotine and its glucuronides (total NNN), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), and cotinine. A cross-sectional analysis was performed with assessment of correlation coefficients.

resultsWhen analyzed based on self-reported cigarettes per day (CPD), no significant correlation with any of the studied tobacco carcinogen metabolites was found. However, urinary cotinine showed significant correlation with total NNN, total NNAL, and 1-HOP. Total NNN, total NNAL, and 1-HOP showed significant correlation with each other suggesting exposure occurs to each proportionally.

conclusionsIn smokers with HNSCC, self-reported tobacco use does not predict actual carcinogen exposure. In contrast, urinary cotinine levels significantly correlate with carcinogen levels. Therefore, urinary cotinine is the preferred value for estimating carcinogen dose in these patients. 1-HOP levels were significantly associated with total NNN and total NNAL suggesting that smokers are exposed to these carcinogens proportionally. These data indicate that utilizing conventional methods of estimating tobacco exposure (CPD) may not accurately approximate exposure to tobacco carcinogens in smokers with HNSCC. These data have implications for future studies focused on screening and epidemiology of smokers with HNSCC. LEVEL OF EVIDENCE: NA

Indexed as

Self ReportAdultAgedBiomarkers, TumorCarcinogensCross-Sectional StudiesFemaleHead and Neck NeoplasmsHumansIncidenceMaleMiddle AgedMinnesotaRetrospective StudiesSmokingSurveys and QuestionnairesBiomarkers, TumorCarcinogensbiomarkerscarcinogenesishead and neck cancermetabolitesTobacco

Identifiers

PMID25877866
PMCPMC4512915
OpenAlexW2136131390

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.