ArticleFunctional & integrative genomics2015
The F-box family genes as key elements in response to salt, heavy mental, and drought stresses in Medicago truncatula.
Article in Functional & integrative genomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 90 citations in OpenAlex.
- Genome-Wide Characterization of the F-Box Gene Family inBiology · 2026Article
- Identification and analysis of salt-responsive F-box genes in upland cotton and the potential role of GhFBX83 in salt stress tolerance through regulating ROS homeostasis.BMC plant biology · 2026Article
- Chromosome-level genome assembly of Youngia japonica reveals evolutionary dynamics underlying adaptation in a synanthropic Asteraceae species.BMC plant biology · 2026Article
- Genome-wide phylogenetic analysis and expression profiling of F-box gene family in Verbena bonariensis under cold stress.BMC plant biology · 2026Article
- Review
- Identification and analysis of drought-responsive F-box genes in upland rice and involvement of OsFBX148 in ABA response and ROS accumulation.BMC plant biology · 2024Article
- Deciphering the mechanism of E3 ubiquitin ligases in plant responses to abiotic and biotic stresses and perspectives on PROTACs for crop resistance.Plant biotechnology journal · 2024Review
- Investigating the genetic basis of salt-tolerance in common bean: a genome-wide association study at the early vegetative stage.Scientific reports · 2024Article
- Identification of Gene Responsible for Conferring Resistance against Race KN2 ofInternational journal of molecular sciences · 2024Article
- The Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2024Article
- Genome-wide association study of salt tolerance at the seed germination stage in lettuce.PloS one · 2024Article
- Role of F-box E3-ubiquitin ligases in plant development and stress responses.Plant cell reports · 2023Review
- A Surprising Diversity of Xyloglucan Endotransglucosylase/Hydrolase in Wheat: New in Sight to the Roles in Drought Tolerance.International journal of molecular sciences · 2023Article
- Insights of auxin signaling F-box genes in wheat (Triticum aestivum L.) and their dynamic expression during the leaf rust infection.Protoplasma · 2023Article
- The herbaceous peony transcription factor WRKY41a promotes secondary cell wall thickening to enhance stem strength.Plant physiology · 2023Article
- Genome-Wide Identification and Expression Analysis of the Xyloglucan Endotransglucosylase/Hydrolase Gene Family in Sweet Potato [International journal of molecular sciences · 2023Article
- Genome-Wide Analysis and Characterization of Eggplant F-Box Gene Superfamily: Gene Evolution and Expression Analysis under Stress.International journal of molecular sciences · 2022Article
- Article
- Genome-Wide Identification and Expression Patterns of the F-box Family in Poplar under Salt Stress.International journal of molecular sciences · 2022Article
- A common F-box gene regulates the leucine homeostasis of Medicago truncatula and Arabidopsis thaliana.Protoplasma · 2022Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
F-box protein is a subunit of Skp1-Rbx1-Cul1-F-box protein (SCF) complex with typically conserved F-box motifs of approximately 40 amino acids and is one of the largest protein families in eukaryotes. F-box proteins play critical roles in selective and specific protein degradation through the 26S proteasome. In this study, we bioinformatically identified 972 putative F-box proteins from Medicago truncatula genome. Our analysis showed that in addition to the conserved motif, the F-box proteins have several other functional domains in their C-terminal regions (e.g., LRRs, Kelch, FBA, and PP2), some of which were found to be M. truncatula species-specific. By phylogenetic analysis of the F-box motifs, these proteins can be classified into three major families, and each family can be further grouped into more subgroups. Analysis of the genomic distribution of F-box genes on M. truncatula chromosomes revealed that the evolutional expansion of F-box genes in M. truncatula was probably due to localized gene duplications. To investigate the possible response of the F-box genes to abiotic stresses, both publicly available and customer-prepared microarrays were analyzed. Most of the F-box protein genes can be responding to salt and heavy metal stresses. Real-time PCR analysis confirmed that some of the F-box protein genes containing heat, drought, salicylic acid, and abscisic acid responsive cis-elements were able to respond to the abiotic stresses.
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