ReviewClinical rheumatology2015
Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk?
Review in Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Severe manifestations of autoimmune syndrome induced by adjuvants (Shoenfeld's syndrome).Immunologic research · 2017Pooled it
- Article
- Exploring Silicone-Induced Lupus Through a Case Report.Mediterranean journal of rheumatology · 2025Article
- Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) in Breast Implants: A Case Report.Cureus · 2025Article
- Somatostatin Receptor Scintigraphy in Autoimmune Syndrome Induced by Silicone Breast Implants: Pre- and Postexplantation Findings.Journal of clinical medicine · 2025Article
- ASIA Syndrome: State-of-the-Art and Future Perspectives.Vaccines · 2024Review
- A Prospective Observational Clinical Cohort of Women with Suspected Breast Implant Illness.Journal of clinical medicine · 2024Article
- Palpitation in women with silicone breast implants: association with autoantibodies against autonomic nervous system.Immunologic research · 2024Article
- Silicone breast implants may contribute to early-onset fetal growth restriction.Clinical rheumatology · 2023Article
- The Prevalence of Hearing Impairments in Women with Silicone Breast Implants.Diseases (Basel, Switzerland) · 2023Article
- Autoimmune/inflammatory syndrome induced by adjuvants in a woman with Hashimoto thyroiditis and familial autoimmunity-a case report and literature review.Frontiers in immunology · 2023Review
- Autoimmune/autoinflammatory syndrome induced by adjuvants: a focus on silicone.Clinical rheumatology · 2022Review
- Deciphering Key Foreign Body Reaction-Related Transcription Factors and Genes Through Transcriptome Analysis.Frontiers in molecular biosciences · 2022Article
- Clinical and Immunological Characteristics of Patients with Biopolymers and Autoimmune Inflammatory Syndrome Induced by Adjuvants.Plastic and reconstructive surgery. Global open · 2021Article
- Improvement of palmoplantar pustulosis after excision of polyacrylamide injected into the nasal region.Case reports in plastic surgery & hand surgery · 2021Article
- Classical Examples of the Concept of the ASIA Syndrome.Biomolecules · 2020Review
- 21-year-old silicone breast implants causing recurrent pneumonia, chest pain and coughing.Respiratory medicine case reports · 2020Article
- Silicone breast implants and depression, fibromyalgia and chronic fatigue syndrome in a rheumatology clinic population.Clinical rheumatology · 2019Article
- Autoimmune/inflammatory syndrome induced by adjuvants-ASIA-related to biomaterials: analysis of 45 cases and comprehensive review of the literature.Immunologic research · 2018Article
- Autoimmune Syndrome Induced by Adjuvants (ASIA) after Silicone Breast Augmentation Surgery.Plastic and reconstructive surgery. Global open · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silicone implants have been in use since the mid-twentieth century, especially in the field of reconstructive breast surgery, and have long been considered as biologically inert and harmless. However, growing body of evidence from the past two decades links silicone with subsequent autoimmunity-related complications, collectively known as autoimmune/inflammatory syndrome induced by adjuvant--ASIA. Previous data suggest that while some patients tend to develop post-exposure autoimmune phenomena such as ASIA, other do not. However, thus far, no criteria for risk stratification were suggested. This current review summarizes the data linking silicone implants and autoimmunity, suggesting means of defining individuals who are at increased risk to develop silicone-induced ASIA, and therefore, a recommendation was made to avoid silicone implantation, e.g., individuals with previously diagnosed autoimmune disorders or with genetic preponderance for hyperactive immune system should not be considered as candidates for silicone implantation.
Indexed as
Identifiers
25877803What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.