ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2015
Objective Estimates Improve Risk Stratification for Primary Graft Dysfunction after Lung Transplantation.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Right Ventricular Stroke Work Index and Its Prognostic Value in a Lung Transplant Population With Group 3 Pulmonary Hypertension.Journal of transplantation · 2026Article
- Machine Learning for Predicting Pulmonary Graft Dysfunction After Double-Lung Transplantation: A Single-Center Study Using Donor, Recipient, and Intraoperative Variables.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Analysis of Primary Graft Dysfunction (PGD) Risk Factors in Lung Transplantation (LuTx) Patients.Clinics and practice · 2024Article
- Impact of Pre-Transplant Left Ventricular Diastolic Pressure on Primary Graft Dysfunction after Lung Transplantation: A Narrative Review.Diagnostics (Basel, Switzerland) · 2024Review
- Impact of recipient and donor pretransplantation body mass index on early postosperative complications after lung transplantation.BMC pulmonary medicine · 2024Observational
- Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation.Frontiers in immunology · 2024Review
- The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.American journal of respiratory and critical care medicine · 2024Article
- Pulmonary, circulatory and renal considerations in the early postoperative management of the lung transplant recipient.Global cardiology science & practice · 2023Review
- The Lung Allocation Score Remains Inequitable for Patients with Pulmonary Arterial Hypertension, Even after the 2015 Revision.American journal of respiratory and critical care medicine · 2023Article
- Don't Inhale: Acute Respiratory Distress Syndrome Risk and Tobacco Exposure in Patients with Sepsis.American journal of respiratory and critical care medicine · 2022Article
- Volatile organic compound profiling to explore primary graft dysfunction after lung transplantation.Scientific reports · 2022Article
- Primary graft dysfunction: what we know.Journal of thoracic disease · 2021Review
- Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021Article
- PreprocurementAmerican journal of respiratory and critical care medicine · 2020Article
- Extracellular histones play a pathogenic role in primary graft dysfunction after human lung transplantation.RSC advances · 2020Article
- Early Graft Dysfunction after Lung Transplantation.Current pulmonology reports · 2018Article
- Transplant options for end stage chronic obstructive pulmonary disease in the context of multidisciplinary treatments.Journal of thoracic disease · 2018Review
- Donor Hypernatremia is Not Related with the Duration of Postoperative Mechanical Ventilation, Primary Graft Dysfunction, or Long-Term Outcome Following Lung Transplantation.Annals of transplantation · 2018Article
- Elevated donor plasminogen activator inhibitor-1 levels and the risk of primary graft dysfunction.Clinical transplantation · 2018Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Primary graft dysfunction (PGD) is a major cause of early mortality after lung transplant. We aimed to define objective estimates of PGD risk based on readily available clinical variables, using a prospective study of 11 centers in the Lung Transplant Outcomes Group (LTOG). Derivation included 1255 subjects from 2002 to 2010; with separate validation in 382 subjects accrued from 2011 to 2012. We used logistic regression to identify predictors of grade 3 PGD at 48/72 h, and decision curve methods to assess impact on clinical decisions. 211/1255 subjects in the derivation and 56/382 subjects in the validation developed PGD. We developed three prediction models, where low-risk recipients had a normal BMI (18.5-25 kg/m(2) ), chronic obstructive pulmonary disease/cystic fibrosis, and absent or mild pulmonary hypertension (mPAP<40 mmHg). All others were considered higher-risk. Low-risk recipients had a predicted PGD risk of 4-7%, and high-risk a predicted PGD risk of 15-18%. Adding a donor-smoking lung to a higher-risk recipient significantly increased PGD risk, although risk did not change in low-risk recipients. Validation demonstrated that probability estimates were generally accurate and that models worked best at baseline PGD incidences between 5% and 25%. We conclude that valid estimates of PGD risk can be produced using readily available clinical variables.
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