Evidence map›Paper›PMID 25877654›Full record

ArticlePsychopharmacology2016

Low-grade inflammation predicts persistence of depressive symptoms.

A Zalli, O Jovanova, W J G Hoogendijk, H Tiemeier, L A Carvalho

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 5 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 5 syntheses or guidelines pooled it, 189 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Circulating versus lipopolysaccharide-induced inflammatory markers as correlates of subthreshold depressive symptoms in older adults.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2020
    Trial
  8. Article
  9. Low 5HTJournal of neurochemistry · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article

43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

A ZalliDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK. a.zalli@ucl.ac.uk.
O JovanovaDepartment of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
W J G HoogendijkDepartment of Psychiatry, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
H TiemeierDepartment of Epidemiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.
L A CarvalhoDepartment of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.
Erasmus MC · NLUniversity College London · GBErasmus University Rotterdam · NL

Funding

British Heart Foundation RG/10/05/28296Medical Research Council MR/L014815/1
6 · The paper itself

Abstract

rationaleEvidence suggests that depression is cross-sectionally and longitudinally associated with activation of inflammatory response system. A few studies, however, have investigated the longitudinal relationship between raised inflammatory biomarkers and persistence of depressive symptoms. We examined the temporal relationship between serum levels of inflammatory biomarkers and persistence of depressive symptoms among older participants.

methodsCenter for Epidemiologic Studies Depression Scale (CES-D) was used to assess depressive symptoms at baseline and at 5-year follow-up in 656 participants (233 men, 423 women) aged >60 years of the Rotterdam Study. Markers of inflammation interleukin (IL)-6, alpha-1-antichymotrypsin (ACT) and C-reactive protein (CRP) were assessed at baseline, and all participants taking antidepressant medications were excluded from the analysis.

resultsNo cross-sectional association was found between IL-6, ACT and CRP with depressive symptoms at baseline. However, higher levels of IL-6 and CRP predicted depressive symptoms at 5-year follow-up. Adjustment for confounding variables had no impact on the observed associations. Similarly, a positive association was found between baseline levels of IL-6 (OR = 2.44, p = 0.030) and CRP (OR = 1.81, p = 0.052) and persistence of depressive symptoms over 5 years.

conclusionOur data suggest that dysregulation of the inflammatory response system is associated with a more severe form of depression more likely to re-occur.

Indexed as

AgedAged, 80 and overAgingalpha 1-AntichymotrypsinBiomarkersC-Reactive ProteinCross-Sectional StudiesCytokinesDepressionFemaleFollow-Up StudiesHumansInflammationInterleukin-6Longitudinal StudiesMalealpha 1-AntichymotrypsinBiomarkersC-Reactive ProteinCytokinesIL6 protein, humanInterleukin-6AgingChronic illnessEpidemiologicalMood disorderPro-inflammatory cytokinesPsychosomatic

Identifiers

PMID25877654
PMCPMC4828485
OpenAlexW1964739425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.