Evidence map›Paper›PMID 25877638›Full record

ArticleDatabase : the journal of biological databases and curation2015

An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools.

Jing Gong, Chunjie Liu, Wei Liu, Yuliang Wu, Zhaowu Ma, Hu Chen, An-Yuan Guo

Open access · goldAbstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Database : the journal of biological databases and curation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.

  1. Pooled it
  2. Validation and Derivation of miRNA-Based Germline Signatures Predicting Radiation Toxicity in Prostate Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
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  17. Role of SNPs in the Biogenesis of Mature miRNAs.BioMed research international · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jing GongDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.
Chunjie LiuDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.
Wei LiuDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.
Yuliang WuDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.
Zhaowu MaDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.
Hu ChenDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China.
An-Yuan GuoDepartment of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People's Republic of China guoay@mail.hust.edu.cn.
Huazhong University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are key regulators of gene expression involved in a broad range of biological processes. MiRNASNP aims to provide single nucleotide polymorphisms (SNPs) in miRNAs and genes that may impact miRNA biogenesis and/or miRNA target binding. Advanced miRNA research provided abundant data about miRNA expression, validated targets and related phenotypic variants. In miRNASNP v2.0, we have updated our previous database with several new data and features, including: (i) expression level and expression correlation of miRNAs and target genes in different tissues, (ii) linking SNPs to the results of genome-wide association studies, (iii) integrating experimentally validated miRNA:mRNA interactions, (iv) adding multiple filters to prioritize functional SNPs. In addition, as a supplement of the database, we have set up three flexible online tools to analyse the influence of novel variants on miRNA:mRNA binding. A new nice web interface was designed for miRNASNP v2.0 allowing users to browse, search and download. We aim to maintain the miRNASNP as a solid resource for function, genetics and disease studies of miRNA-related SNPs. Database URL: http://bioinfo.life. hust.edu.cn/miRNASNP2/

Indexed as

Databases, Nucleic AcidGene Expression RegulationInternetUser-Computer InterfaceAnimalsGenome-Wide Association StudyHumansMicroRNAsPolymorphism, Single NucleotideMicroRNAs

Identifiers

PMID25877638
PMCPMC4397995
OpenAlexW1984397688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.