ArticleGenome biology and evolution2015
Evolution of gene regulation during transcription and translation.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 59 citations in OpenAlex.
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- Ribosome Pausing Negatively Regulates Protein Translation in Maize Seedlings during Dark-to-Light Transitions.International journal of molecular sciences · 2024Article
- Translation variation across genetic backgrounds reveals a post-transcriptional buffering signature in yeast.Nucleic acids research · 2024Article
- Bayesian linear mixed model with multiple random effects for prediction analysis on high-dimensional multi-omics data.Bioinformatics (Oxford, England) · 2023Article
- Evolutionary trade-off and mutational bias could favor transcriptional over translational divergence within paralog pairs.PLoS genetics · 2023Article
- Regulatory Divergence as a Mechanism for X-Autosome Incompatibilities in Caenorhabditis Nematodes.Genome biology and evolution · 2023Article
- The prognostic and immune infiltration role of ITGB superfamily members in non-small cell lung cancer.American journal of translational research · 2022Article
- Functional Annotation of a Full-Length Transcriptome and Identification of Genes Associated with Flower Development inPlants (Basel, Switzerland) · 2021Article
- Lineage-specific selection and the evolution of virulence in theProceedings of the National Academy of Sciences of the United States of America · 2021Article
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- Speciation and the developmental alarm clock.eLife · 2020Review
- Hybrid Incompatibilities and Transgressive Gene Expression Between Two Closely Related Subspecies ofFrontiers in genetics · 2020Article
- Is it useful to use several "omics" for obtaining valuable results?Molecular biology reports · 2019Review
- Variable protein homeostasis in housekeeping and non-housekeeping pathways under mycotoxins stress.Scientific reports · 2019Article
- Novel insights into global translational regulation through Pumilio family RNA-binding protein Puf3p revealed by ribosomal profiling.Current genetics · 2019Article
- Fine-Tuning the Expression of Duplicate Genes by Translational Regulation inFrontiers in plant science · 2019Article
- Multiplexing polysome profiling experiments to study translation in Escherichia coli.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Understanding how gene regulation evolves is a key area in the current evolutionary field. Gene regulation occurs at various levels. Previous work on the evolution of gene regulation has largely focused on gene transcription. In this study, we used a recently developed ribosomal footprint profiling method to investigate how gene regulation evolves at both the transcription (mRNA abundance) and translation (ribosomal density) levels. By constructing a hybrid between Saccharomyces cerevisiae (Scer) and Saccharomyces bayanus (Sbay), which diverged ∼20 Ma, and quantifying transcriptome and translatome in both parental strains and their hybrid, we showed that translation is much more conserved than transcription, mostly due to the buffering effect of translational regulation for the transcriptional divergence. More conservation in translation than transcription is also confirmed by the inheritance mode of transcription and translation between two species. Furthermore, cis and trans effects are widely involved in changes at both transcription and translation levels. Finally, our results showed that genes with certain functions and sequence features might employ specific modes for evolution at these two critical levels of gene regulation. Our results demonstrated that it is essential to investigate the evolution of gene regulation at various levels from different genetic backgrounds to obtain a complete picture of its evolutionary modes in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.