Evidence map›Paper›PMID 25877483›Full record

ArticleBMC infectious diseases2015

Epidemiologic, clinical, diagnostic and therapeutic aspects of visceral leishmaniasis in renal transplant recipients: experience from thirty cases.

Avelar Alves de Silva, Álvaro Pacheco e Silva Filho, Ricardio de Castro Cinta Sesso, Ronaldo de Matos Esmeraldo, Cláudia Maria Costa de Oliveira, Paula Frassinetti Fernandes, Rodrigo Alves de Oliveira, Leila Silveira Veira de Silva, Valencio Pereira de Carvalho, Carlos Henrique Nery Costa and 3 more

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Tropical Infections in the Context of Kidney Transplantation in Latin America.The American journal of tropical medicine and hygiene · 2021
    Review
  4. Article
  5. Review
  6. New insights into leishmaniasis in the immunosuppressed.PLoS neglected tropical diseases · 2018
    Review
  7. Review
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Avelar Alves de Silva
Álvaro Pacheco e Silva Filho
Ricardio de Castro Cinta Sesso
Ronaldo de Matos Esmeraldo
Cláudia Maria Costa de Oliveira
Paula Frassinetti Fernandes
Rodrigo Alves de Oliveira
Leila Silveira Veira de Silva
Valencio Pereira de Carvalho
Carlos Henrique Nery Costa
Jesusmar Ximenes Andrade
Diana Marisa Barros da Silva
Roosevelt Valente Chaves
Santa Casa Hospital · BRUniversidade Regional do Cariri · BRHospital Universitário Walter Cantídio · BRUniversidade Federal de São Paulo · BRUniversidade Federal do Piauí · BRHospital Geral de Fortaleza · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVisceral leishmaniasis is a disease caused by the protozoan Leishmania sp. and is transmitted by Lutzomyia longipalpis (sand fly). In renal transplant recipients, visceral leishmaniasis causes severe damage to the liver, spleen, and hematopoietic system, as well as poor outcomes for patients with transplanted kidneys. This study describes the largest series of cases of visceral leishmaniasis in renal transplant recipients, providing important information about the diagnostic routines and therapeutic strategies in this patient population.

methodsA retrospective, descriptive study was performed to analyze the distribution and evaluate the extent of the epidemiologic, clinical, diagnostic and therapeutic aspects of 30 renal transplant recipients from endemic regions who presented with visceral leishmaniasis in the post-transplantation period.

resultsIn this study, visceral leishmaniasis was more frequent in men (80%). The mean age of presentation was 40 ± 10.5 years. The majority of patients worked in urban areas (66.7%), cohabitated with domestic animals (90%), and were from low-income households. In 73.3% of cases, diagnosis was made by direct isolation of Leishmania forms. Patients were treated with liposomal amphotericin, resulting in a high degree of disease remission (80%).

conclusionsThis study describes the largest series of visceral leishmaniasis in renal transplant recipients and expands clinical-epidemiological knowledge for transplantation teams to perform adequate disease management for this specific patient population.

Indexed as

Immunocompromised HostKidney TransplantationAdultAge DistributionAmphotericin BAnimalsAnimals, DomesticAntiprotozoal AgentsFemaleHumansImmunosuppressive AgentsKidney DiseasesLeishmaniaLeishmaniasis, VisceralLiver DiseasesMaleAmphotericin BAntiprotozoal AgentsImmunosuppressive Agentsliposomal amphotericin B

Identifiers

PMID25877483
PMCPMC4381535
OpenAlexW2084930312

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.