ReviewCold Spring Harbor perspectives in biology2015
Associative learning in invertebrates.
Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Operant conditioning through positive reinforcement in the ghost crab (Ocypode quadrata).Learning & behavior · 2026Article
- Article
- Striatal Acetylcholine Dip-Rebound Is Induced by Direct-Pathway Neurons and Encode Action-Outcome Contingency.bioRxiv : the preprint server for biology · 2026Article
- Low-dimensional signatures of neuronal activity associated with long-term operant conditioning in Aplysia.Communications biology · 2025Article
- Review
- Repeated stimulation of feeding mechanoafferents inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Division of labor for defensive retaliation and preemption by the peripheral and central nervous systems in the nudibranch Berghia.Current biology : CB · 2024Article
- Article
- Molecular mechanisms underlying hyperglycemia associated cognitive decline.IBRO neuroscience reports · 2023Review
- Physiological and pathological consequences of exosomes at the blood-brain-barrier interface.Cell communication and signaling : CCS · 2023Review
- Identification of three elevenin receptors and roles of elevenin disulfide bond and residues in receptor activation in Aplysia californica.Scientific reports · 2023Article
- Exaptation and Evolutionary Adaptation in Nociceptor Mechanisms Driving Persistent Pain.Brain, behavior and evolution · 2023Review
- Article
- Molecular insights from the crabFrontiers in molecular neuroscience · 2023Review
- Article
- Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives.Biomolecules · 2022Review
- The evolution of synaptic and cognitive capacity: Insights from the nervous system transcriptome ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Review
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- Associative Conditioning Is a Robust Systemic Behavior in Unicellular Organisms: An Interspecies Comparison.Frontiers in microbiology · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
This work reviews research on neural mechanisms of two types of associative learning in the marine mollusk Aplysia, classical conditioning of the gill- and siphon-withdrawal reflex and operant conditioning of feeding behavior. Basic classical conditioning is caused in part by activity-dependent facilitation at sensory neuron-motor neuron (SN-MN) synapses and involves a hybrid combination of activity-dependent presynaptic facilitation and Hebbian potentiation, which are coordinated by trans-synaptic signaling. Classical conditioning also shows several higher-order features, which might be explained by the known circuit connections in Aplysia. Operant conditioning is caused in part by a different type of mechanism, an intrinsic increase in excitability of an identified neuron in the central pattern generator (CPG) for feeding. However, for both classical and operant conditioning, adenylyl cyclase is a molecular site of convergence of the two signals that are associated. Learning in other invertebrate preparations also involves many of the same mechanisms, which may contribute to learning in vertebrates as well.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.