ArticleIn vitro cellular & developmental biology. Animal2015
Establishment of immortalized murine mesothelial cells and a novel mesothelioma cell line.
Article in In vitro cellular & developmental biology. Animal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 37 citations in OpenAlex.
- Multi-stromal organoid co-culture modelling reveals epithelial-fibroblast heterogeneity in pancreatic cancer and pancreatitis.Nature cell biology · 2026Article
- Establishment and Characterization of Canine Malignant Mesothelioma Cells.Yonago acta medica · 2026Article
- Use of a novel microbiome modulator improves anticancer immunity in a murine model of malignant pleural mesothelioma.JTCVS open · 2024Article
- Article
- Prognostic Value of EMT Gene Signature in Malignant Mesothelioma.International journal of molecular sciences · 2023Article
- A panel of emerging EMT genes identified in malignant mesothelioma.Scientific reports · 2022Article
- Host Mesothelin Expression Increases Ovarian Cancer Metastasis in the Peritoneal Microenvironment.International journal of molecular sciences · 2021Article
- IRF3 Knockout Results in Partial or Complete Rejection of Murine Mesothelioma.Journal of clinical medicine · 2021Article
- Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis.Cancer research · 2020Article
- Article
- The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cellsOncotarget · 2019Article
- Modulation of Calretinin Expression in Human Mesothelioma Cells Reveals the Implication of the FAK and Wnt Signaling Pathways in Conferring Chemoresistance towards Cisplatin.International journal of molecular sciences · 2019Article
- Influence of gene modification in biological behaviors and responses of mouse lung telocytes to inflammation.Journal of translational medicine · 2019Article
- Modeling Epidermal Growth Factor Inhibitor-mediated Enhancement of Photodynamic Therapy Efficacy Using 3D Mesothelioma Cell Culture.Photochemistry and photobiology · 2019Article
- Calretinin Functions in Malignant Mesothelioma Cells Cannot Be Replaced by the Closely Related CaInternational journal of molecular sciences · 2018Article
- Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma.International journal of oncology · 2018Article
- Calretinin promotes invasiveness and EMT in malignant mesothelioma cells involving the activation of the FAK signaling pathway.Oncotarget · 2018Article
- Preclinical investigation of folate receptor-targeted nanoparticles for photodynamic therapy of malignant pleural mesothelioma.International journal of oncology · 2018Article
- Article
- Putative cancer stem cells may be the key target to inhibit cancer cell repopulation between the intervals of chemoradiation in murine mesothelioma.BMC cancer · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesothelial cells are susceptible to asbestos fiber-induced cytotoxicity and on longer time scales to transformation; the resulting mesothelioma is a highly aggressive neoplasm that is considered as incurable at the present time Zucali et al. (Cancer Treatment Reviews 37:543-558, 2011). Only few murine cell culture models of immortalized mesothelial cells and mesothelioma cell lines exist to date. We generated SV40-immortalized cell lines derived from wild-type (WT) and neurofibromatosis 2 (merlin) heterozygote (Nf2+/-) mice, both on a commonly used genetic background, C57Bl/6J. All immortalized mesothelial clones consistently grow in DMEM supplemented with fetal bovine serum. Cells can be passaged for more than 40 times without any signs of morphological changes or a decrease in proliferation rate. The tumor suppressor gene NF2 is one of the most frequently mutated genes in human mesothelioma, but its detailed function is still unknown. Thus, these genotypically distinct cell lines likely relevant for malignant mesothelioma formation are expected to serve as useful in vitro models, in particular to compare with in vivo studies in mice of the same genotype. Furthermore, we generated a novel murine mesothelioma cell line RN5 originating from an Nf2+/- mouse subjected to repeated crocidolite exposure. RN5 cells are highly tumorigenic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.