ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015
Measurement of cortical porosity of the proximal femur improves identification of women with nonvertebral fragility fractures.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Cortical indices, DXA, and FRAX as indicators of bone fragility: a comparative human cadaveric study.JBMR plus · 2026Article
- Short-term risk of fracture is increased by deficits in cortical and trabecular bone microarchitecture independent of DXA BMD and FRAX: Bone Microarchitecture International Consortium (BoMIC) prospective cohorts.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Cortical bone density by quantitative computed tomography mirrors disorders of bone structure in bone biopsy of non-dialysis CKD patients.Bone reports · 2022Article
- Cortical Bone Loss Following Gastric Bypass Surgery Is Not Primarily Endocortical.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Axial Transmission: Techniques, Devices and Clinical Results.Advances in experimental medicine and biology · 2022Article
- Computed Tomography Osteodensitometry for Assessment of Bone Mineral Density of the Canine Head-Preliminary Results.Animals : an open access journal from MDPI · 2021Article
- Differential effects of abaloparatide and teriparatide on hip cortical volumetric BMD by DXA-based 3D modeling.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
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- Deterioration of Cortical and Trabecular Microstructure Identifies Women With Osteopenia or Normal Bone Mineral Density at Imminent and Long-Term Risk for Fragility Fracture: A Prospective Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Effect of diode laser biostimulation compared to Teriparatide on induced osteoporosis in rats: an animal study from Egypt.International journal of clinical and experimental pathology · 2020Article
- MRI-derived bone porosity index correlates to bone composition and mechanical stiffness.Bone reports · 2019Article
- Bone Marrow Adipose Tissue Quantification by Imaging.Current osteoporosis reports · 2019Review
- Computed tomography porosity and spherical indentation for determining cortical bone millimetre-scale mechanical properties.Scientific reports · 2019Article
- Article
- Increased Cortical Porosity and Reduced Trabecular Density Are Not Necessarily Synonymous With Bone Loss and Microstructural Deterioration.JBMR plus · 2019Article
- Article
- PET-MRI for the Study of Metabolic Bone Disease.Current osteoporosis reports · 2018Review
- The Influence of Cortical Porosity on the Strength of Bone During Growth and Advancing Age.Current osteoporosis reports · 2018Review
- Volumetric Bone Mineral Density and Failure Load of Distal Limbs Predict Incident Clinical Fracture Independent HR-pQCT BMD and Failure Load Predicts Incident Clinical Fracture of FRAX and Clinical Risk Factors Among Older Men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Quantitative two-dimensional ultrashort echo time magnetization transfer (2D UTE-MT) imaging of cortical bone.Magnetic resonance in medicine · 2018Article
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10 authors.
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Abstract
unlabelledWe tested whether cortical porosity of the proximal femur measured using StrAx1.0 software provides additional information to areal bone mineral density (aBMD) or Fracture Risk Assessment Tool (FRAX) in differentiating women with and without fracture. Porosity was associated with fracture independent of aBMD and FRAX and identified additional women with fractures than by osteoporosis or FRAX thresholds.
introductionNeither aBMD nor the FRAX captures cortical porosity, a major determinant of bone strength. We therefore tested whether combining porosity with aBMD or FRAX improves identification of women with fractures.
methodsWe quantified femoral neck (FN) aBMD using dual-energy X-ray absorptiometry, FRAX score, and femoral subtrochanteric cortical porosity using StrAx1.0 software in 211 postmenopausal women aged 54-94 years with nonvertebral fractures and 232 controls in Tromsø, Norway. Odds ratios (ORs) were calculated using logistic regression analysis.
resultsWomen with fractures had lower FN aBMD, higher FRAX score, and higher cortical porosity than controls (all p < 0.001). Each standard deviation higher porosity was associated with fracture independent of FN aBMD (OR 1.39; 95% confidence interval 1.11-1.74) and FRAX score (OR 1.58; 1.27-1.97) in all women combined. Porosity was also associated with fracture independent of FRAX score in subgroups with normal FN aBMD (OR 1.88; 1.21-2.94), osteopenia (OR 1.40; 1.06-1.85), but not significantly in those with osteoporosis (OR 1.48; 0.68-3.23). Of the 211 fracture cases, only 18 women (9%) were identified using FN aBMD T-score < -2.5, 45 women (21%) using FRAX threshold >20%, whereas porosity >80th percentile identified 61 women (29%). Porosity identified 26% additional women with fractures than identified by the osteoporosis threshold and 21% additional women with fractures than by this FRAX threshold.
conclusionsCortical porosity is a risk factor for fracture independent of aBMD and FRAX and improves identification of women with fracture.
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