ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Integrated innate mechanisms involved in airway allergic inflammation to the serine protease subtilisin.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Occupational Asthma Due to Subtilisin: The Power of Specific Inhalation Challenge.La Medicina del lavoro · 2025Article
- Article
- Purification and characterization of a serine protease from organic dust and elucidation of its inductive effects on lung inflammatory mediators.American journal of physiology. Lung cellular and molecular physiology · 2023Article
- Initiation of type 2 immunity at barrier surfaces.Mucosal immunology · 2023Review
- Immune sensing of food allergens promotes aversive behaviour.bioRxiv : the preprint server for biology · 2023Article
- Allergen protease-activated stress granule assembly and gasdermin D fragmentation control interleukin-33 secretion.Nature immunology · 2022Article
- Integrated OMICs Approach for the Group 1 Protease Mite-Allergen of House Dust MiteInternational journal of molecular sciences · 2022Article
- Review
- MyD88 regulates a prolonged adaptation response to environmental dust exposure-induced lung disease.Respiratory research · 2020Article
- Club Cell TRPV4 Serves as a Damage Sensor Driving Lung Allergic Inflammation.Cell host & microbe · 2020Article
- Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care.Allergy · 2019Review
- Selective cleavage of fibrinogen by diverse proteinases initiates innate allergic and antifungal immunity through CD11b.The Journal of biological chemistry · 2019Article
- Noninvasive allergic sinus congestion and resolution assessments using microcomputed tomography imaging.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Benefits of antifungal therapy in asthma patients with airway mycosis: A retrospective cohort analysis.Immunity, inflammation and disease · 2018Article
- Characterization of a novel, papain-inducible murine model of eosinophilic rhinosinusitis.International forum of allergy & rhinology · 2018Article
- Environmental allergens induce allergic inflammation through proteolytic maturation of IL-33.Nature immunology · 2018Article
- Orchestration of epithelial-derived cytokines and innate immune cells in allergic airway inflammation.Cytokine & growth factor reviews · 2018Review
- Stenotrophomonas maltophilia Serine Protease StmPr1 Induces Matrilysis, Anoikis, and Protease-Activated Receptor 2 Activation in Human Lung Epithelial Cells.Infection and immunity · 2017Article
- Multi-Approach Analysis for the Identification of Proteases within Birch Pollen.International journal of molecular sciences · 2017Article
- Identification of Proteases and Protease Inhibitors in Allergenic and Non-Allergenic Pollen.International journal of molecular sciences · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
Proteases are recognized environmental allergens, but little is known about the mechanisms responsible for sensing enzyme activity and initiating the development of allergic inflammation. Because usage of the serine protease subtilisin in the detergent industry resulted in an outbreak of occupational asthma in workers, we sought to develop an experimental model of allergic lung inflammation to subtilisin and to determine the immunological mechanisms involved in type 2 responses. By using a mouse model of allergic airway disease, we have defined in this study that s.c. or intranasal sensitization followed by airway challenge to subtilisin induces prototypic allergic lung inflammation, characterized by airway eosinophilia, type 2 cytokine release, mucus production, high levels of serum IgE, and airway reactivity. These allergic responses were dependent on subtilisin protease activity, protease-activated receptor-2, IL-33R ST2, and MyD88 signaling. Also, subtilisin stimulated the expression of the proallergic cytokines IL-1α, IL-33, thymic stromal lymphopoietin, and the growth factor amphiregulin in a human bronchial epithelial cell line. Notably, acute administration of subtilisin into the airways increased lung IL-5-producing type 2 innate lymphoid cells, which required protease-activated receptor-2 expression. Finally, subtilisin activity acted as a Th2 adjuvant to an unrelated airborne Ag-promoting allergic inflammation to inhaled OVA. Therefore, we established a murine model of occupational asthma to a serine protease and characterized the main molecular pathways involved in allergic sensitization to subtilisin that potentially contribute to initiate allergic airway disease.
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