Evidence map›Paper›PMID 25876667›Full record

ArticleAddiction (Abingdon, England)2015

Estimating the number of people with hepatitis C virus who have ever injected drugs and have yet to be diagnosed: an evidence synthesis approach for Scotland.

Teresa C Prevost, Anne M Presanis, Avril Taylor, David J Goldberg, Sharon J Hutchinson, Daniela De Angelis

Abstract read
In one paragraph

Article in Addiction (Abingdon, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  12. Evidence Synthesis for Stochastic Epidemic Models.Statistical science : a review journal of the Institute of Mathematical Statistics · 2018
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  13. Review
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Teresa C PrevostMRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
Anne M PresanisMRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.
Avril TaylorSchool of Culture, Media and Society, University of the West of Scotland, Paisley, UK.
David J GoldbergHealth Protection Scotland, NHS National Services Scotland, Glasgow, UK.
Sharon J HutchinsonHealth Protection Scotland, NHS National Services Scotland, Glasgow, UK.
Daniela De AngelisMRC Biostatistics Unit, Cambridge Institute of Public Health, Cambridge, UK.

Funding

Medical Research Council MC_U105260556
6 · The paper itself

Abstract

aimsTo estimate the number of people who have ever injected drugs (defined here as PWID) living in Scotland in 2009 who have been infected with the hepatitis C virus (HCV) and to quantify and characterize the population remaining undiagnosed.

methodsInformation from routine surveillance (n=22616) and survey data (n=2511) was combined using a multiparameter evidence synthesis approach to estimate the size of the PWID population, HCV antibody prevalence and the proportion of HCV antibody prevalent cases who have been diagnosed, in subgroups defined by recency of injecting (in the last year or not), age (15-34 and 35-64 years), gender and region of residence (Greater Glasgow and Clyde and the rest of Scotland).

resultsHCV antibody-prevalence among PWID in Scotland during 2009 was estimated to be 57% [95% CI=52-61%], corresponding to 46657 [95% credible interval (CI)=33812-66803] prevalent cases. Of these, 27434 (95% CI=14636-47564) were undiagnosed, representing 59% [95% CI=43-71%] of prevalent cases. Among the undiagnosed, 83% (95% CI=75-89%) were PWID who had not injected in the last year and 71% (95% CI=58-85%) were aged 35-64 years.

conclusionsThe number of undiagnosed hepatitis C virus-infected cases in Scotland appears to be particularly high among those who have injected drugs more than 1 year ago and are more than 35 years old.

Indexed as

AdolescentAdultAge DistributionEpidemiologic MethodsFemaleHepatitis C AntibodiesHepatitis C, ChronicHumansMaleMiddle AgedScotlandSex DistributionSubstance Abuse, IntravenousYoung AdultHepatitis C AntibodiesEvidence synthesishepatitis Cpeople who inject drugsprevalence

Identifiers

PMID25876667
PMCPMC4744705

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