ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Early hemorrhage triggers metabolic responses that build up during prolonged shock.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 74 citations in OpenAlex.
- Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.Transfusion · 2018Trial
- Multiomic analyses of longitudinal plasma samples identify thromboinflammation endotypes and trajectories in patients with trauma.Science translational medicine · 2026Article
- Obesity influences the biological response to injury: a multi-omics analysis.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Emilia sonchifolia (L.) DC. inhibits the growth of Methicillin-Resistant Staphylococcus epidermidis by modulating its physiology through multiple mechanisms.Scientific reports · 2025Article
- Integrated proteomic and metabolomic profiling of lymph after trauma-induced hypercoagulopathy and antithrombotic therapy.Thrombosis journal · 2024Article
- Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice.Scientific reports · 2024Article
- IL-6 mediates the hepatic acute phase response after prerenal azotemia in a clinically defined murine model.American journal of physiology. Renal physiology · 2023Article
- Endothelial Cell Phenotypes Demonstrate Different Metabolic Patterns and Predict Mortality in Trauma Patients.International journal of molecular sciences · 2023Observational
- Omics Markers of Red Blood Cell Transfusion in Trauma.International journal of molecular sciences · 2022Article
- Metabolic systems analysis identifies a novel mechanism contributing to shock in patients with endotheliopathy of trauma (EoT) involving thromboxane A2 and LTCMatrix biology plus · 2022Article
- Article
- Cerebral effects of resuscitation with either epinephrine or vasopressin in an animal model of hemorrhagic shock.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Article
- Metabolic Profiling of a Porcine Combat Trauma-Injury Model Using NMR and Multi-Mode LC-MS Metabolomics-A Preliminary Study.Metabolites · 2020Article
- Red blood cell metabolism in Rhesus macaques and humans: comparative biology of blood storage.Haematologica · 2020Article
- COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status.JCI insight · 2020Observational
- Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock.Shock (Augusta, Ga.) · 2020Article
- Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.Blood transfusion = Trasfusione del sangue · 2019Article
- Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel.Journal of proteome research · 2019Article
- Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice.Kidney international · 2019Article
- Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates.Molecular metabolism · 2018Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Metabolic staging after trauma/hemorrhagic shock is a key driver of acidosis and directly relates to hypothermia and coagulopathy. Metabolic responses to trauma/hemorrhagic shock have been assayed through classic biochemical approaches or NMR, thereby lacking a comprehensive overview of the dynamic metabolic changes occurring after shock. Sprague-Dawley rats underwent progressive hemorrhage and shock. Baseline and postshock blood was collected, and late hyperfibrinolysis was assessed (LY30 >3%) in all of the tested rats. Extreme and intermediate time points were collected to assay the dynamic changes of the plasma metabolome via ultra-high performance liquid chromatography-mass spectrometry. Sham controls were used to determine whether metabolic changes could be primarily attributable to anesthesia and supine positioning. Early hemorrhage-triggered metabolic changes that built up progressively and became significant during sustained hemorrhagic shock. Metabolic phenotypes either resulted in immediate hypercatabolism, or late hypercatabolism, preceded by metabolic deregulation during early hemorrhage in a subset of rats. Hemorrhagic shock consistently promoted hyperglycemia, glycolysis, Krebs cycle, fatty acid, amino acid, and nitrogen metabolism (urate and polyamines), and impaired redox homeostasis. Early dynamic changes of the plasma metabolome are triggered by hemorrhage in rats. Future studies will determine whether metabolic subphenotypes observed in rats might be consistently observed in humans and pave the way for tailored resuscitative strategies.
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