ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2015
Intensity-dependent alterations in the excitability of cortical and spinal projections to the knee extensors during isometric and locomotor exercise.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Exercise intensity affects acute neurotrophic and neurophysiological responses poststroke.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Trial
- On the role of descending drive and group III/IV muscle afferent feedback in modulating corticomotoneuronal excitability during knee-extensor exercise.The Journal of physiology · 2026Article
- Corticospinal Excitability During Explosive Voluntary Contractions and Its Association With Rapid Torque Production.The European journal of neuroscience · 2025Article
- Effects of short- and long-term vibration therapy on maximum voluntary isometric contraction and muscle activity in quadriceps and antagonist muscles.Journal of physical therapy science · 2025Article
- Acute Effects of Neuromuscular Electrical Stimulation on Contralateral Plantar Flexor Neuromuscular Function.Biology · 2022Article
- A Subject-Tailored Variability-Based Platform for Overcoming the Plateau Effect in Sports Training: A Narrative Review.International journal of environmental research and public health · 2022Review
- Motor cortex plasticity and visuomotor skill learning in upper and lower limbs of endurance-trained cyclists.European journal of applied physiology · 2022Article
- Corticospinal Excitability Is Lower During Eccentric Than Concentric Cycling in Men.Frontiers in physiology · 2022Article
- Gait and Neuromuscular Changes Are Evident in Some Masters Club Level Runners 24-h After Interval Training Run.Frontiers in sports and active living · 2022Article
- Corticomotor excitability of gluteus maximus and hip extensor strength: The influence of sex.Human movement science · 2021Article
- Ascorbate attenuates cycling exercise-induced neuromuscular fatigue but fails to improve exertional dyspnea and exercise tolerance in COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Heart failure with preserved ejection fraction diminishes peripheral hemodynamics and accelerates exercise-induced neuromuscular fatigue.American journal of physiology. Heart and circulatory physiology · 2021Article
- Tongue Strength Training Increases Daytime Upper Airway Stability in Rats.Nature and science of sleep · 2021Article
- On the Influence of Group III/IV Muscle Afferent Feedback on Endurance Exercise Performance.Exercise and sport sciences reviews · 2020Review
- Corticospinal excitability is altered similarly following concentric and eccentric maximal contractions.European journal of applied physiology · 2020Article
- Corticomotor function is associated with quadriceps rate of torque development in individuals with ACL surgery.Experimental brain research · 2020Article
- Corticospinal-Evoked Responses from the Biceps Brachii during Arm Cycling across Multiple Power Outputs.Brain sciences · 2019Article
- Intensity matters: effects of cadence and power output on corticospinal excitability during arm cycling are phase and muscle dependent.Journal of neurophysiology · 2018Article
- Impact of age on the development of fatigue during large and small muscle mass exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Fatigue-related group III/IV muscle afferent feedback facilitates intracortical inhibition during locomotor exercise.The Journal of physiology · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the role of exercise intensity and associated central motor drive in determining corticomotoneuronal excitability. Ten participants performed a series of nonfatiguing (3 s) isometric single-leg knee extensions (ISO; 10-100% of maximal voluntary contractions, MVC) and cycling bouts (30-160% peak aerobic capacity, W peak). At various exercise intensities, electrical potentials were evoked in the vastus lateralis (VL) and rectus femoris (RF) via transcranial magnetic stimulation (motor-evoked potentials, MEP), and electrical stimulation of both the cervicomedullary junction (cervicomedullary evoked potentials, CMEP) and the femoral nerve (maximal M-waves, M max). Whereas M max remained unchanged in both muscles (P > 0.40), voluntary electromyographic activity (EMG) increased in an exercise intensity-dependent manner for ISO and cycling exercise in VL and RF (both P < 0.001). During ISO exercise, MEPs and CMEPs progressively increased in VL and RF until a plateau was reached at ∼ 75% MVC; further increases in contraction intensity did not cause additional changes (P > 0.35). During cycling exercise, VL-MEPs and CMEPs progressively increased by ∼ 65% until a plateau was reached at W peak. In contrast, RF MEPs and CMEPs progressively increased by ∼ 110% throughout the tested cycling intensities without the occurrence of a plateau. Furthermore, alterations in EMG below the plateau influenced corticomotoneuronal excitability similarly between exercise modalities. In both exercise modalities, the MEP-to-CMEP ratio did not change with exercise intensity (P > 0.22). In conclusion, increases in exercise intensity and EMG facilitates the corticomotoneuronal pathway similarly in isometric knee extension and locomotor exercise until a plateau occurs at a submaximal exercise intensity. This facilitation appears to be primarily mediated by increases in excitability of the motoneuron pool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.