Evidence map›Paper›PMID 25876630›Full record

ReviewCold Spring Harbor symposia on quantitative biology2014

Animal-to-Animal Variability in Neuromodulation and Circuit Function.

Albert W Hamood, Eve Marder

Erratum issuedOpen access · diamondAbstract readReview
In one paragraph

Review in Cold Spring Harbor symposia on quantitative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. From the Neuroscience of Individual Variability to Climate Change.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  14. Article
  15. Review
  16. Intrinsic plasticity and birdsong learning.Neurobiology of learning and memory · 2021
    Review
  17. Article
  18. Systems Neuroscience of Natural Behaviors in Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Review
  19. Neuromodulation and Individuality.Frontiers in behavioral neuroscience · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Albert W HamoodVolen Center and Biology Department, Brandeis University, Brandeis University, Waltham, Massachusetts 02454.
Eve MarderVolen Center and Biology Department, Brandeis University, Brandeis University, Waltham, Massachusetts 02454 marder@brandeis.edu.
Brandeis University · US

Funding

NEUROTRANSMITTER MODULATION OF NEURONAL CIRCUITSR01NS017813 · NINDS · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 1985 to 2009
$3.3M
Quantitative Biology: a Graduate Curriculum Linking the Physical and Biomedical ST32EB009419 · NIBIB · BRANDEIS UNIVERSITY · PI GELLES, JEFF, KONDEV, JANE · 2009 to 2018
$2.8M
Neurotransmitter Modulation of Neuronal CircuitsR37NS017813 · NINDS · BRANDEIS UNIVERSITY · PI MARDER, EVE E · 2010 to 2016
$2.6M
Long-Term Regulation of Excitability in an Episodic Pattern GeneratorF31NS080420 · NINDS · BRANDEIS UNIVERSITY · PI HAMOOD, ALBERT WILLIAM · 2012 to 2014
$88k
NIBIB NIH HHS T32 EB009419NINDS NIH HHS F31 NS080420NINDS NIH HHS NS 17813NINDS NIH HHS NS F31 080420NINDS NIH HHS R01 NS017813NINDS NIH HHS R37 NS017813
6 · The paper itself

Abstract

Each animal alive in the world is different from all other individuals, while sharing most attributes of form and function with others of the same species. Still other attributes are shared within a phylum, and still others are common to most eukaryotic organisms. All animals have mechanisms that modulate the strength of their synapses or alter the intrinsic excitability of component neurons. What animal-to-animal variability in behavior arises from differences in neuronal structure, ion channel expression, or connectivity, and what variability arises from neuromodulation of brain states? Conversely, can robust behavior be maintained despite variability in circuit components by the action of neuromodulatory inputs? These are fundamental issues relevant to all nervous systems that have been illuminated by many years of study of the small, rhythmic motor circuits found in the crustacean stomatogastric nervous system.

Indexed as

AnimalsMotor ActivityNerve NetNeural ConductionNeurons

Identifiers

PMID25876630
PMCPMC4610821
OpenAlexW2051778869

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.