ArticleCold Spring Harbor symposia on quantitative biology2014
The Brainstem Oscillator for Whisking and the Case for Breathing as the Master Clock for Orofacial Motor Actions.
Article in Cold Spring Harbor symposia on quantitative biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Dexterous single sniffs for ethological active olfaction.Science advances · 2026Article
- Multiple cortical systems influence a single vibrissa muscle.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Global coordination of brain activity by the breathing cycle.Nature reviews. Neuroscience · 2025Review
- The pupillary respiratory-phase response: pupil size is smallest around inhalation onset and largest during exhalation.The Journal of physiology · 2025Article
- A flowchart for adequate controls in virus-based monosynaptic tracing experiments identified Cre-independent leakage of the TVA receptor in RΦGT mice.BMC neuroscience · 2024Article
- Low- and high-level coordination of orofacial motor actions.Current opinion in neurobiology · 2023Review
- Interchangeable Role of Motor Cortex and Reafference for the Stable Execution of an Orofacial Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Theory of hierarchically organized neuronal oscillator dynamics that mediate rodent rhythmic whisking.Neuron · 2022Article
- The whisking oscillator circuit.Nature · 2022Article
- Breathing Rhythm and Pattern and Their Influence on Emotion.Annual review of neuroscience · 2022Review
- Evidence of intermediate reticular formation involvement in swallow pattern generation, recorded optically in the neonate rat sagittally sectioned hindbrain.Journal of neurophysiology · 2021Article
- Coding of whisker motion across the mouse face.eLife · 2019Article
- Trpm4 ion channels in pre-Bötzinger complex interneurons are essential for breathing motor pattern but not rhythm.PLoS biology · 2019Article
- Functional brain stem circuits for control of nose motion.Journal of neurophysiology · 2019Article
- The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response.Frontiers in cellular neuroscience · 2019Article
- The mesencephalic-hypoglossal nuclei loop as a possible central pattern generator for rhythmical whisking in rats.Experimental brain research · 2018Article
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- 3D reconstruction and standardization of the rat facial nucleus for precise mapping of vibrissal motor networks.Neuroscience · 2018Article
- Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions.Neuroscience · 2018Review
- Breathing to inspire and arouse.Science (New York, N.Y.) · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Whisking and sniffing are predominant aspects of exploratory behavior in rodents. We review evidence that these motor rhythms are coordinated by the respiratory patterning circuitry in the ventral medulla. A recently described region in the intermediate reticular zone of the medulla functions as an autonomous whisking oscillator, whose neuronal output is reset upon each breath by input from the pre-Bötzinger complex. Based on similarities between this neuronal circuit architecture and that of other orofacial behaviors, we propose that the pre-Bötzinger complex, which projects broadly to premotor regions throughout the intermediate reticular zone of the medulla, functions as a master clock to coordinate multiple orofacial actions involved in exploratory and ingestive behaviors. We then extend the analysis of whisking to the relatively slow control of the midpoint of the whisk. We conjecture, in a manner consistent with breathing as the "master clock" for all orofacial behaviors, that slow control optimizes the position of sensors whereas the breathing rhythm provides a means to perceptually bind the inputs from different orofacial modalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.