ArticleAmerican journal of respiratory and critical care medicine2015
Loss of Lung Health from Young Adulthood and Cardiac Phenotypes in Middle Age.
Article in American journal of respiratory and critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Normal age-related decline in forced vital capacity: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Inorganic arsenic and respiratory health, from early life exposure to sex-specific effects: A systematic review.Environmental research · 2016Pooled it
- Synergistic effects of tDCS combined with aerobic exercise on pulmonary function and heart rate in sedentary young people.Scientific reports · 2025Trial
- Effect of twice daily inhaled albuterol on cardiopulmonary exercise outcomes, dynamic hyperinflation, and symptoms in secondhand tobacco-exposed persons with preserved spirometry and air trapping: a randomized controlled trial.BMC pulmonary medicine · 2024Trial
- Review
- Challenges in the Early Diagnosis, Screening and Management of Heart Failure in Patients with Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2026Review
- The impact of child and adolescent health on adult respiratory health: the evidence, gaps and priorities.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Immunotherapeutic targeting of aging-associated isoDGR motif in chronic lung inflammation.Aging cell · 2025Article
- Article
- Gender Difference in the Relationship between Extrapulmonary Factors and Reduced Lung Function in Early Adulthood.Journal of clinical medicine · 2024Article
- Associations of a plant-centered diet and lung function across early to mid-adulthood: The CARDIA Lung Study.Respiratory research · 2024Article
- Comprehensive and Safe Decongestion in Acutely Decompensated Heart Failure.Current heart failure reports · 2022Review
- Association of Pulmonary Function With Late-Life Cardiac Function and Heart Failure Risk: The ARIC Study.Journal of the American Heart Association · 2022Article
- Comorbid Chronic Obstructive Pulmonary Disease and Heart Failure: Shared Risk Factors and Opportunities to Improve Outcomes.Annals of the American Thoracic Society · 2022Article
- Remote exposure to secondhand tobacco smoke is associated with lower exercise capacity through effects on oxygen pulse, a proxy of cardiac stroke volume.BMJ open respiratory research · 2022Article
- Cardiovascular Morbidity in Individuals with Impaired FEV1.Current cardiology reports · 2022Review
- Association of 71 cardiovascular disease-related plasma proteins with pulmonary function in the community.PloS one · 2022Article
- Low lung function, sudden cardiac death and non-fatal coronary events in the general population.BMJ open respiratory research · 2021Article
- Associations between lung function and future cardiovascular morbidity and overall mortality in a predominantly First Nations population: a cohort study.The Lancet regional health. Western Pacific · 2021Article
- The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8.Journal of the American College of Cardiology · 2021Review
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
rationaleChronic lung diseases are associated with cardiovascular disease. How these associations evolve from young adulthood forward is unknown. Understanding the preclinical history of these associations could inform prevention strategies for common heart-lung conditions.
objectivesTo use the Coronary Artery Risk Development in Young Adults (CARDIA) study to explore the development of heart-lung interactions.
methodsWe analyzed cardiac structural and functional measurements determined by echocardiography at Year 25 of CARDIA and measures of pulmonary function over 20 years in 3,000 participants. MEASUREMENTS AND MAIN
resultsDecline in FVC from peak was associated with larger left ventricular mass (β = 6.05 g per SD of FVC decline; P < 0.0001) and greater cardiac output (β = 0.109 L/min per SD of FVC decline; P = 0.001). Decline in FEV1/FVC ratio was associated with smaller left atrial internal dimension (β = -0.038 cm per SD FEV1/FVC decline; P < 0.0001) and lower cardiac output (β = -0.070 L/min per SD of FEV1/FVC decline; P = 0.03). Decline in FVC was associated with diastolic dysfunction (odds ratio, 3.39; 95% confidence interval, 1.37-8.36; P = 0.006).
conclusionsPatterns of loss of lung health are associated with specific cardiovascular phenotypes in middle age. Decline in FEV1/FVC ratio is associated with underfilling of the left heart and low cardiac output. Decline in FVC with preserved FEV1/FVC ratio is associated with left ventricular hypertrophy and diastolic dysfunction. Cardiopulmonary interactions apparent with common complex heart and lung diseases evolve concurrently from early adulthood forward.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.