ArticleZeitschrift fur Rheumatologie2015
Association between the ACE gene I/D polymorphism and osteoporosis in a Turkish population.
Article in Zeitschrift fur Rheumatologie, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- Genetic Scores ofInternational journal of environmental research and public health · 2021Article
- Long-term use of angiotensin-converting enzyme inhibitors protects against bone loss in African-American elderly men.Archives of osteoporosis · 2017Observational
- Relationship among angiotensin-converting enzyme polymorphism, cardiovascular risk, and osteoporotic fractures.European journal of rheumatology · 2016Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to assess the relationship between osteoporosis and the angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism in a Turkish population.
methodsThe study group consisted of 238 unrelated women with osteoporosis and 124 unrelated healthy female controls. All participants, patients and healthy controls, were of Turkish origin from the central region of Turkey. Genomic DNA was isolated from whole venous blood samples using a commercial DNA isolation kit. The ACE gene I/D polymorphism was analysed by polymerase chain reaction and gel electrophoresis.
resultsFrequencies of the DD, ID and II genotypes in the patients were 44.5, 41.2 and 14.3 %, and in the controls they were 25.0, 51.6 and 23.4 %, respectively. A significant difference was observed between patients and controls according to genotype frequency (p=0.001). D and I allele frequencies of the I/D polymorphism were 65.1 and 34.9 % in the patient group and 50.8 and 49.2 % in the control group, respectively (p<0.001).
conclusionThe ACE gene I/D polymorphism could be a genetic factor associated with osteoporosis.
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