Evidence map›Paper›PMID 25875972›Full record

Observational studyRadiology2015

Diagnostic Accuracy of Preoperative Gadoxetic Acid-enhanced 3-T MR Imaging for Malignant Liver Lesions by Using Ex Vivo MR Imaging-matched Pathologic Findings as the Reference Standard.

Eduardo A C Costa, Guilherme M Cunha, Emmanuil Smorodinsky, Irene Cruite, An Tang, Robert M Marks, Lisa Clark, Tanya Wolfson, Anthony Gamst, Jason K Sicklick and 4 more

Open access · greenAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Radiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Evaluation of tongue squamous cell carcinoma resection margins using ex-vivo MR.International journal of computer assisted radiology and surgery · 2017
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Eduardo A C CostaFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Guilherme M CunhaFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Emmanuil SmorodinskyFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Irene CruiteFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
An TangFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Robert M MarksFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Lisa ClarkFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Tanya WolfsonFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Anthony GamstFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Jason K SicklickFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Alan HemmingFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Michael R PetersonFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Michael S MiddletonFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
Claude B SirlinFrom the Liver Imaging Group, Department of Radiology, University of California-San Diego, 408 Dickinson St, San Diego, CA 92103-8226 (E.A.C.C., G.M.C., E.S., I.C., A.T., R.M.M., L.C., M.S.M., C.B.S.); Department of Radiology, Naval Medical Center San Diego, San Diego, Calif (R.M.M.); Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California-San Diego, San Diego, Calif (T.W., A.G.); Department of Surgery and Moores Cancer Center, University of California-San Diego, San Diego, Calif (J.K.S., A.H.); and Western Washington Pathology and Multicare Health System, Tacoma, Wash (M.R.P.).
University of California, San Diego · USMoores Cancer CenterMultiCare Health System · USNaval Medical Center San Diego · USSan Diego Supercomputer Center · US

Funding

Novel Allosteric Kinase Inhibitors Target Imatinib-Resistant GISTK08CA168999 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SICKLICK, JASON KEITH · 2014 to 2018
$888k
NCI NIH HHS K08 CA168999
6 · The paper itself

Abstract

purposeTo determine per-lesion sensitivity and positive predictive value (PPV) of gadoxetic acid-enhanced 3-T magnetic resonance (MR) imaging for the diagnosis of malignant lesions by using matched (spatially correlated) hepatectomy pathologic findings as the reference standard. Materials and

methodsIn this prospective, institutional review board-approved, HIPAA-compliant study, 20 patients (nine men, 11 women; mean age, 59 years) with malignant liver lesions who gave written informed consent underwent preoperative gadoxetic acid-enhanced 3-T MR imaging for surgical planning. Two image sets were independently analyzed by three readers to detect liver lesions (set 1 without and set 2 with hepatobiliary phase [HBP] images). Hepatectomy specimen ex vivo MR imaging assisted in matching gadoxetic acid-enhanced 3-T MR imaging findings with pathologic findings. Interreader agreement was assessed by using the Cohen κ coefficient. Per-lesion sensitivity and PPV were calculated.

resultsCohen κ values were 0.64-0.76 and 0.57-0.84, and overall per-lesion sensitivity was 45% (42 of 94 lesions) to 56% (53 of 94 lesions) and 58% (55 of 94 lesions) to 64% (60 of 94 lesions) for sets 1 and 2, respectively. The addition of HBP imaging did not affect interreader agreement but significantly improved overall sensitivity for one reader (P < .05) and almost for another (P = .05). Sensitivity for 0.2-0.5-cm lesions was 0% (0 of 26 lesions) to 8% (two of 26 lesions) for set 1 and 4% (one of 26 lesions) to 12% (three of 26 lesions) for set 2. Sensitivity for 0.6-1.0-cm lesions was 28% (nine of 32 lesions) to 59% (19 of 32 lesions) for set 1 and 66% (21 of 32 lesions) to 69% (22 of 32 lesions) for set 2. Sensitivity for lesions at least 1.0 cm in diameter was at least 81% (13 of 16 lesions) for set 1 and was not improved for set 2. PPV was 98% (56 of 57 lesions) to 100% (60 of 60 lesions) for all readers without differences between image sets or lesion size.

conclusionGadoxetic acid-enhanced 3-T MR imaging provides high per-lesion sensitivity and PPV for preoperative malignant liver lesion detection overall, although sensitivity for 0.2-0.5-cm malignant lesions is poor.

Indexed as

Contrast MediaGadolinium DTPAAdultAgedAged, 80 and overCross-Sectional StudiesFemaleHumansLiver NeoplasmsMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsPreoperative CareProspective StudiesReference StandardsContrast MediaGadolinium DTPAgadolinium ethoxybenzyl DTPA

Identifiers

PMID25875972
PMCPMC4962530
OpenAlexW2115938382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.