ArticlePloS one2015
Dynamics of biofilm formation and the interaction between Candida albicans and methicillin-susceptible (MSSA) and -resistant Staphylococcus aureus (MRSA).
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
68 citing papers in PubMed.
- Tolerance of outbreak-associated Candida parapsilosis isolates to antiseptics in a dry surface biofilm model.Scientific reports · 2026Article
- Biofilm formation directly correlates with cell viability in Candida tropicalis on polypropylene.Applied microbiology and biotechnology · 2026Article
- Formation of Streptococcus mutans Polymicrobial Biofilms in the Presence of Lactobacillus plantarum and Candida albicans.European journal of dentistry · 2026Article
- Understanding Heterogeneity and Tolerance of Dual Candida albicans-Staphylococcus aureus Biofilms to Cold Atmospheric Plasma and Antimicrobial Combinations.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Article
- Cyanobacterium Chroococcus sp. Mediated Silver Nanoparticles to Fight Candida albicans and Staphylococcus aureus Biofilms: Effect of Dual Species Conditions.Applied biochemistry and biotechnology · 2025Article
- MixedJournal of fungi (Basel, Switzerland) · 2025Article
- Assessment of Metabolic Alterations Induced by Halogenated Additives and Antifungal Activity of Extracts from the Endophytic FungusMetabolites · 2025Article
- A simple silicone elastomer colonization model highlights complexities ofJournal of medical microbiology · 2025Article
- Characteristic of Virulence and Parameters of Mixed Biofilm Formed by Carbapenem-ResistantPathogens (Basel, Switzerland) · 2025Article
- The appropriate nutrient conditions for methicillin-resistant Staphylococcus aureus and Candida albicans dual-species biofilm formation in vitro.Scientific reports · 2025Article
- Exploring the antimicrobial potential of lactobacilli against early-stage and mature biofilms ofFrontiers in chemistry · 2025Article
- Effect of Mn(II) and Co(II) on Anti-Pharmaceuticals (Basel, Switzerland) · 2024Article
- Co-colonization of methicillin-resistant Staphylococcus aureus and Candida spp. in children with malignancies.AMB Express · 2024Article
- Studying mixed-species biofilms of Candida albicans and Staphylococcus aureus using evolutionary game theory.PloS one · 2024Article
- Time-lapse mesoscopy ofMicrobiology (Reading, England) · 2024Article
- Surface adherence and vacuolar internalization of bacterial pathogens to the Candida spp. cells: Mechanism of persistence and propagation.Journal of advanced research · 2023Review
- Isolation of lectin from Musa acuminata for its antibiofilm potential against Methicillin-resistant Staphylococcus aureus and its synergistic effect with Enterococcus species.Archives of microbiology · 2023Article
- The Anti-Virulence Effect ofAntibiotics (Basel, Switzerland) · 2022Article
- Antimicrobial-free graphene nanocoating decreases fungal yeast-to-hyphal switching and maturation of cross-kingdom biofilms containing clinical and antibiotic-resistant bacteria.Biomaterials and biosystems · 2022Article
- Real-time monitoring of mono- and dual-species biofilm formation and eradication using microfluidic platform.Scientific reports · 2022Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polymicrobial biofilms are an understudied and a clinically relevant problem. This study evaluates the interaction between C. albicans, and methicillin- susceptible (MSSA) and resistant (MRSA) S. aureus growing in single- and dual-species biofilms. Single and dual species adhesion (90 min) and biofilms (12, 24, and 48 h) were evaluated by complementary methods: counting colony-forming units (CFU mL-1), XTT-reduction, and crystal violet staining (CV). The secretion of hydrolytic enzymes by the 48 h biofilms was also evaluated using fluorimetric kits. Scanning electron microscopy (SEM) was used to assess biofilm structure. The results from quantification assays were compared using two-way ANOVAs with Tukey post-hoc tests, while data from enzymatic activities were analyzed by one-way Welch-ANOVA followed by Games-Howell post hoc test (α = 0.05). C. albicans, MSSA and MRSA were able to adhere and to form biofilm in both single or mixed cultures. In general, all microorganisms in both growth conditions showed a gradual increase in the number of cells and metabolic activity over time, reaching peak values between 12 h and 48 h (ρ<0.05). C. albicans single- and dual-biofilms had significantly higher total biomass values (ρ<0.05) than single biofilms of bacteria. Except for single MRSA biofilms, all microorganisms in both growth conditions secreted proteinase and phospholipase-C. SEM images revealed extensive adherence of bacteria to hyphal elements of C. albicans. C. albicans, MSSA, and MRSA can co-exist in biofilms without antagonism and in an apparent synergistic effect, with bacteria cells preferentially associated to C. albicans hyphal forms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.