Evidence map›Paper›PMID 25875598›Full record

ArticlePloS one2015

National income inequality and declining GDP growth rates are associated with increases in HIV diagnoses among people who inject drugs in Europe: a panel data analysis.

Georgios K Nikolopoulos, Anastasios Fotiou, Eleftheria Kanavou, Clive Richardson, Marios Detsis, Anastasia Pharris, Jonathan E Suk, Jan C Semenza, Claudia Costa-Storti, Dimitrios Paraskevis and 4 more

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  13. Income Inequality, HIV Stigma, and Preventing HIV Disease Progression in Rural Communities.Prevention science : the official journal of the Society for Prevention Research · 2019
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  14. Article
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  16. Observational
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  18. Molecular investigation of HIV-1 cross-group transmissions during an outbreak among people who inject drugs (2011-2014) in Athens, Greece.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2018
    Article
  19. Review
  20. A Risk Analysis Approach to Prioritizing Epidemics: Ebola Virus Disease in West Africa as a Case Study.Risk analysis : an official publication of the Society for Risk Analysis · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Georgios K NikolopoulosDepartment of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece; Hellenic Centre for Disease Control and Prevention, Amarousio, Greece.
Anastasios FotiouGreek Reitox Focal Point of the EMCDDA, University Mental Health Research Institute, Athens, Greece; Department of Psychiatry, Athens University Medical School, Athens, Greece.
Eleftheria KanavouGreek Reitox Focal Point of the EMCDDA, University Mental Health Research Institute, Athens, Greece.
Clive RichardsonGreek Reitox Focal Point of the EMCDDA, University Mental Health Research Institute, Athens, Greece; Panteion University of Social and Political Sciences, Athens, Greece.
Marios DetsisDepartment of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.
Anastasia PharrisEuropean Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Jonathan E SukEuropean Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Jan C SemenzaEuropean Centre for Disease Prevention and Control (ECDC), Stockholm, Sweden.
Claudia Costa-StortiEuropean Monitoring Centre for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal.
Dimitrios ParaskevisDepartment of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.
Vana SypsaDepartment of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.
Melpomeni-Minerva MallioriDepartment of Psychiatry, Athens University Medical School, Athens, Greece.
Samuel R FriedmanNational Development and Research Institutes, New York, New York, United States of America.
Angelos HatzakisDepartment of Hygiene, Epidemiology and Medical Statistics, Athens University Medical School, Athens, Greece.

Funding

Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan, Courtney McKnight · 1998 to 2026
$38.9M
BEHAVIORAL SCI TRAINING IN DRUG ABUSE RESEARCHT32DA007233 · NIDA · PUBLIC HEALTH SOLUTIONS · PI GOLDSAMT, LLOYD A · 1985 to 2023
$20.2M
Preventing HIV Transmission by Recently-Infected Drug UsersDP1DA034989 · NIDA · NATIONAL DEVELOPMENT AND RESEARCH INSTITUTES, INC. · PI FRIEDMAN, SAMUEL R · 2012 to 2016
$3.8M
NIDA NIH HHS DP1 DA034989NIDA NIH HHS P30 DA011041NIDA NIH HHS P30 DA11041NIDA NIH HHS T32 DA007233
6 · The paper itself

Abstract

backgroundThere is sparse evidence that demonstrates the association between macro-environmental processes and drug-related HIV epidemics. The present study explores the relationship between economic, socio-economic, policy and structural indicators, and increases in reported HIV infections among people who inject drugs (PWID) in the European Economic Area (EEA).

methodsWe used panel data (2003-2012) for 30 EEA countries. Statistical analyses included logistic regression models. The dependent variable was taking value 1 if there was an outbreak (significant increase in the national rate of HIV diagnoses in PWID) and 0 otherwise. Explanatory variables included the growth rate of Gross Domestic Product (GDP), the share of the population that is at risk for poverty, the unemployment rate, the Eurostat S80/S20 ratio, the Gini coefficient, the per capita government expenditure on health and social protection, and variables on drug control policy and drug-using population sizes. Lags of one to three years were investigated.

findingsIn multivariable analyses, using two-year lagged values, we found that a 1% increase of GDP was associated with approximately 30% reduction in the odds of an HIV outbreak. In GDP-adjusted analyses with three-year lagged values, the effect of the national income inequality on the likelihood of an HIV outbreak was significant [S80/S20 Odds Ratio (OR) = 3.89; 95% Confidence Interval (CI): 1.15 to 13.13]. Generally, the multivariable analyses produced similar results across three time lags tested.

interpretationGiven the limitations of ecological research, we found that declining economic growth and increasing national income inequality were associated with an elevated probability of a large increase in the number of HIV diagnoses among PWID in EEA countries during the last decade. HIV prevention may be more effective if developed within national and European-level policy contexts that promote income equality, especially among vulnerable groups.

Indexed as

Economic DevelopmentGross Domestic ProductEuropeHIV InfectionsHumansInjectionsLogistic ModelsPovertySubstance-Related Disorders

Identifiers

PMID25875598
PMCPMC4398461

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.