ArticleClinical oral investigations2016
Salivary and serum leptin levels in patients with squamous cell carcinoma of the buccal mucosa.
Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 12 citations in OpenAlex.
- Review
- Estimation of Serum Leptin, Adiponectin, and Malondialdehyde Levels in Tobacco-Induced Oral Squamous Cell Carcinoma: ELISA-Based Study.South Asian journal of cancer · 2025Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
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Abstract
objectivesLeptin levels are associated with appetite and energy expenditure in healthy individuals. The present study aims to evaluate serum and salivary leptin concentrations in patients with squamous cell carcinoma of the buccal mucosa. MATERIALS AND
methodsEnrolled participants in this study included 41 patients with squamous cell carcinoma of the buccal mucosa and 40 healthy control patients. Serum leptin levels were measured via enzyme-linked immunosorbent assay (ELISA) method in all subjects and reported in units of nanograms per millilitre. Salivary leptin levels were measured by a highly sensitive and specific non-equilibrium version of a dedicated custom radioimmunoassay.
resultsA significant reduction in salivary and serum leptin levels in patients with squamous cell carcinoma of the buccal mucosa was observed in comparison to control subjects. In addition, a significant correlation was shown between serum and salivary leptin levels on one hand and body mass index, with various histopathological and TNM (tumour nodes metastasis) staging variants of squamous cell carcinoma of the buccal mucosa on another. A highly significant correlation was shown between salivary and serum leptin levels in both groups.
conclusionThe results of this study demonstrate a possible mechanism of salivary and serum leptin levels in squamous cell carcinoma of the buccal mucosa. CLINICAL RELEVANCE: Salivary leptin might play a role in squamous cell carcinoma of the buccal mucosa.
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