Evidence map›Paper›PMID 25875389›Full record

ArticleAtherosclerosis2015

Secondhand smoke exposure is associated with increased carotid artery intima-media thickness: the Bogalusa Heart Study.

Wei Chen, Miaoying Yun, Camilo Fernandez, Shengxu Li, Dianjianyi Sun, Chin-Chih Lai, Yingxiao Hua, Fu Wang, Tao Zhang, Sathanur R Srinivasan and 2 more

Registry-linked trialAbstract read
In one paragraph

Article in Atherosclerosis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005129 (The Bogalusa Heart Study), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00005129 active not recruitingnot on this map

The Bogalusa Heart Study

TypeobservationalSponsorTulane UniversityRan1973 to 2029Enrolled11,737ConditionsAtherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Disease
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Wei ChenDepartment of Epidemiology, Tulane University, New Orleans, LA, USA. Electronic address: wchen1@tulane.edu.
Miaoying YunDepartment of Epidemiology, Tulane University, New Orleans, LA, USA; College of Life and Environment Sciences, Minzu University, Beijing, China.
Camilo FernandezDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Shengxu LiDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Dianjianyi SunDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Chin-Chih LaiDepartment of Epidemiology, Tulane University, New Orleans, LA, USA; Department of Cardiology, Peking Union Medical College Hospital, Beijing, China.
Yingxiao HuaDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Fu WangDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Tao ZhangDepartment of Epidemiology, Tulane University, New Orleans, LA, USA; Department of Biostatistics, School of Public Health, Shandong University, Jinan, China.
Sathanur R SrinivasanDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.
Carolyn C JohnsonDepartment of Global Community Health and Behavioral Sciences, Tulane University, New Orleans, LA, USA.
Gerald S BerensonDepartment of Epidemiology, Tulane University, New Orleans, LA, USA.

Funding

EVOLUTION OF CARDIOVASCULAR RISK WITH NORMAL AGINGR01AG016592 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2000 to 2015
$11.7M
Tulane Building Interdisciplinary Research Careers in Women's Health (BIRCWH)K12HD043451 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI KROUSEL-WOOD, MARIE · 2002 to 2023
$9.9M
Childhood Secondhand Smoke and Longitudinal Cardiovascular Risk ProfileR01ES021724 · NIEHS · TULANE UNIVERSITY OF LOUISIANA · PI CHEN, WEI · 2012 to 2014
$1.8M
NIA NIH HHS 2R01AG016592NIA NIH HHS R01 AG016592NICHD NIH HHS K12 HD043451NICHD NIH HHS K12HD043451NIEHS NIH HHS 5R01ES021724NIEHS NIH HHS R01 ES021724
6 · The paper itself

Abstract

backgroundSecondhand smoke (SHS) exposure increases cardiovascular disease risk. The objective of this study was to examine the association of SHS exposure in childhood and adulthood with adult arterial thickness.

methodsThe study cohort consisted of 415 nonsmoking adults (301 whites and 114 blacks; ages 26.2-48.0 years) enrolled in 2004-2010. The arterial wall thickness was measured as common, bulb and internal carotid artery intima-media thickness (IMT). SHS exposure data in childhood and adulthood were obtained by a questionnaire survey.

resultsIncreased adult composite carotid IMT was significantly associated with SHS exposure (regression coefficient, β = 53.1 μm, p < 0.001) after adjusting for race, age, gender, education, income, body mass index, systolic blood pressure, LDL cholesterol and triglycerides/HDL cholesterol ratio, with blacks (β = 81.2 μm, p = 0.005) and whites (β = 38.9 μm, p = 0.017) showing the same direction of the association. Furthermore, the SHS exposure in childhood showed a relatively stronger association with increased carotid IMT than the exposure in adulthood based on standardized βs (0.180 vs. 0.106); the same trend in the difference between childhood and adulthood exposure was noted for duration of SHS exposure (0.186 vs. 0.145). The covariates-adjusted composite carotid IMT showed a significant increasing trend by the order of exposure status of none, adulthood only, childhood only and both (p for trend<0.001).

conclusionsIf the relationship is causal, the associations observed in this study suggest that more awareness should be raised on the dangers of SHS exposure during childhood so that its effect may be mitigated and controlled early in the cardiovascular disease process.

Indexed as

Carotid Intima-Media ThicknessAdultAge FactorsBlack or African AmericanCarotid Artery, CommonCarotid Artery DiseasesCarotid Artery, InternalEnvironmental ExposureFemaleHumansLouisianaMaleMiddle AgedPredictive Value of TestsRetrospective StudiesRisk AssessmentTobacco Smoke PollutionArterial wall thicknessChildhoodSecondhand smoke

Identifiers

PMID25875389
PMCPMC4441551

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.