Evidence map›Paper›PMID 25875206›Full record

ArticleSystematic reviews2015

Health state utility values for diabetic retinopathy: protocol for a systematic review and meta-analysis.

Christopher J Sampson, Jonathan C Tosh, Christopher P Cheyne, Deborah Broadbent, Marilyn James

Open access · goldAbstract read
In one paragraph

Article in Systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  3. Review
  4. Article
  5. Article
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Christopher J SampsonDivision of Rehabilitation and Ageing, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK. chris.sampson@nottingham.ac.uk.
Jonathan C ToshSchool of Health and Related Research, University of Sheffield, Regent Court, Sheffield, S1 4DA, UK. j.tosh@sheffield.ac.uk.
Christopher P CheyneDepartment of Biostatistics, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK. c.p.cheyne@liverpool.ac.uk.
Deborah BroadbentDepartment of Eye and Vision Science, Royal Liverpool University Hospital, Prescot Street, Liverpool, L7 8XP, UK. deborah.broadbent@rlbuht.nhs.uk.
Marilyn JamesDivision of Rehabilitation and Ageing, School of Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK. marilyn.james@nottingham.ac.uk.
University of Liverpool · GBUniversity of Nottingham · GBUniversity of Sheffield · GB

Funding

Department of Health RP-PG-1210-12016
6 · The paper itself

Abstract

backgroundPeople with diabetic retinopathy tend to have lower levels of health-related quality of life than individuals with no retinopathy. Strategies for screening and treatment have been shown to be cost-effective. In order to reduce the bias in cost-effectiveness estimates, systematic reviews of health state utility values (HSUVs) are crucial for health technology assessment and the development of decision analytic models. A review and synthesis of HSUVs for the different stages of disease progression in diabetic retinopathy has not previously been conducted. METHODS/

designWe will conduct a systematic review of the available literature that reports HSUVs for people with diabetic retinopathy, in correspondence with current stage of disease progression and/or visual acuity. We will search Medline, EMBASE, Web of Science, Cost-Effectiveness Analysis Registry, Centre for Reviews and Dissemination Database, and EconLit to identify relevant English-language articles. Data will subsequently be synthesized using linear mixed effects modeling meta-regression. Additionally, reported disease severity classifications will be mapped to a four-level grading scale for diabetic retinopathy. DISCUSSION: The systematic review and meta-analysis will provide important evidence for future model-based economic evaluations of technologies for diabetic retinopathy. The meta-regression will enable the estimation of utility values at different disease stages for patients with particular characteristics and will also highlight where the design of the study and HSUV instrument have influenced the reported utility values. We believe this protocol to be the first of its kind to be published. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42014012891.

Indexed as

Cost-Benefit AnalysisHealth StatusQuality of LifeSeverity of Illness IndexTechnology Assessment, BiomedicalClinical ProtocolsDiabetic RetinopathyHumansMeta-Analysis as TopicResearch DesignSystematic Reviews as Topic

Identifiers

PMID25875206
PMCPMC4342097
OpenAlexW2153749668

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.